Document Detail

Elevated angiotensin II and vasopressin in primary hyperparathyroidism. Angiotensin II infusion studies before and after removal of the parathyroid adenoma.
MedLine Citation:
PMID:  2522705     Owner:  NLM     Status:  MEDLINE    
In order to evaluate the role of calcium metabolism in blood pressure regulation, 15 patients with primary hyperparathyroidism and 9 healthy control subjects were studied before and during angiotensin II infusion. The patients were re-investigated 2-5 months after removal of the parathyroid adenoma. Blood pressure, plasma levels of angiotensin II, aldosterone, arginine vasopressin, and atrial natriuretic peptide, and creatinine clearance were determined. Blood pressure and the blood pressure response to angiotensin II infusion were both the same before and after the operation. Angiotensin II and arginine vasopressin during basal conditions were significantly higher before than after the operation (angiotensin II: 17 (median) to 10 pmol/l, P less than 0.02; arginine vasopressin: 2.9 to 1.9 pmol/l, P less than 0.01), whereas aldosterone, atrial natriuretic peptide, and creatinine clearance were unchanged. During angiotensin II infusion, aldosterone, arginine vasopressin, and atrial natriuretic peptide increased to approximately the same levels before and after the operation. Blood pressure was not correlated to any of the hormones measured. Thus, patients with primary hyperparathyroidism have elevated plasma levels of angiotensin II and arginine vasopressin which may be compensatory phenomena counteracting volume depletion owing to a decreased renal concentrating ability induced by hypercalcemia, and owing to PTH-induced inhibition of renal sodium reabsorption.
B Jespersen; E B Pedersen; P Charles; H Danielsen; H Juhl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  120     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-21     Completed Date:  1989-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  362-8     Citation Subset:  IM    
Department of Medicine C, Aarhus Kommunehospital, Denmark.
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MeSH Terms
Adenoma / surgery*
Aldosterone / blood
Angiotensin II / administration & dosage*,  blood
Arginine Vasopressin / blood*
Atrial Natriuretic Factor / blood
Blood Pressure / drug effects
Hyperparathyroidism / blood*,  physiopathology,  therapy
Middle Aged
Osmolar Concentration
Parathyroid Neoplasms / surgery*
Potassium / blood
Reg. No./Substance:
11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7440-09-7/Potassium; 85637-73-6/Atrial Natriuretic Factor

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