Document Detail


Elevated angiotensin II and vasopressin in primary hyperparathyroidism. Angiotensin II infusion studies before and after removal of the parathyroid adenoma.
MedLine Citation:
PMID:  2522705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to evaluate the role of calcium metabolism in blood pressure regulation, 15 patients with primary hyperparathyroidism and 9 healthy control subjects were studied before and during angiotensin II infusion. The patients were re-investigated 2-5 months after removal of the parathyroid adenoma. Blood pressure, plasma levels of angiotensin II, aldosterone, arginine vasopressin, and atrial natriuretic peptide, and creatinine clearance were determined. Blood pressure and the blood pressure response to angiotensin II infusion were both the same before and after the operation. Angiotensin II and arginine vasopressin during basal conditions were significantly higher before than after the operation (angiotensin II: 17 (median) to 10 pmol/l, P less than 0.02; arginine vasopressin: 2.9 to 1.9 pmol/l, P less than 0.01), whereas aldosterone, atrial natriuretic peptide, and creatinine clearance were unchanged. During angiotensin II infusion, aldosterone, arginine vasopressin, and atrial natriuretic peptide increased to approximately the same levels before and after the operation. Blood pressure was not correlated to any of the hormones measured. Thus, patients with primary hyperparathyroidism have elevated plasma levels of angiotensin II and arginine vasopressin which may be compensatory phenomena counteracting volume depletion owing to a decreased renal concentrating ability induced by hypercalcemia, and owing to PTH-induced inhibition of renal sodium reabsorption.
Authors:
B Jespersen; E B Pedersen; P Charles; H Danielsen; H Juhl
Related Documents :
24009695 - Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injur...
12234305 - Vasopeptidase inhibition and ang-(1-7) in the spontaneously hypertensive rat.
12596885 - Mechanism of action of hypotensive prostaglandins in patients with essential hypertension.
7143155 - Use of continuous saralasin infusion to control hypertension.
9717605 - Influence of arrhythmias on accuracy of non-invasive blood pressure monitors.
8878085 - Difficulty in estimating localized bowel contraction by colonic manometry: a simultaneo...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  120     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-21     Completed Date:  1989-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  362-8     Citation Subset:  IM    
Affiliation:
Department of Medicine C, Aarhus Kommunehospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenoma / surgery*
Adult
Aged
Aldosterone / blood
Angiotensin II / administration & dosage*,  blood
Arginine Vasopressin / blood*
Atrial Natriuretic Factor / blood
Blood Pressure / drug effects
Female
Humans
Hyperparathyroidism / blood*,  physiopathology,  therapy
Male
Middle Aged
Osmolar Concentration
Parathyroid Neoplasms / surgery*
Potassium / blood
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 113-79-1/Arginine Vasopressin; 52-39-1/Aldosterone; 7440-09-7/Potassium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A deficient response of atrial natriuretic peptide to volume overload in Gordon's syndrome.
Next Document:  Platelet dysfunction in acute megakaryoblastic leukemia.