Document Detail

Elevated aldosterone in amniotic fluid and maternal blood has diagnostic potential in pregnancies complicated with a fetus of Bartter syndrome.
MedLine Citation:
PMID:  16260879     Owner:  NLM     Status:  MEDLINE    
Pregnancies with fetuses affected with the Bartter syndrome, an autosomal recessive disorder of hyperreninism and hyperaldosteronism, are complicated by early onset of polyhydramnios which results in preterm deliveries. We have assessed biochemical changes in amniotic fluid and the mother's blood with a view to early diagnosis. Aldosterone levels of both amniotic fluid and the mother's blood were found to be increased at 27 weeks of gestation, while electrolyte levels did not differ significantly from those reported earlier for controls. After birth the baby suffered from polyuria with hyponatremia, hypomagnesemia and hypercalciuria which could be controlled by treatment with sodium chloride and magnesium. Elevated aldosterone thus might be a useful marker for early diagnostic purposes.
Tamao Nakanishi; Nobuhiro Suzumori; Haruo Mizuno; Kazutaka Suzuki; Takeshi Sato; Mitsuyo Tanemura; Yoshikatsu Suzuki; Kaoru Suzumori
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  20     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-11-01     Completed Date:  2006-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  481-4     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Nagoya City University Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Aldosterone / analysis*,  blood
Amniotic Fluid / chemistry
Bartter Syndrome / complications,  diagnosis*
Biological Markers / analysis
Fetal Diseases / diagnosis*
Polyhydramnios / etiology
Prenatal Diagnosis
Reg. No./Substance:
0/Biological Markers; 52-39-1/Aldosterone

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