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Elevated urinary fibronectin excretion predicts poor outcome in patients with primary chronic glomerulonephritis.
MedLine Citation:
PMID:  20484935     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Fibronectin (FN) is one of the major matrix proteins in the kidney. The accumulation of FN fragments in inflamed glomeruli could contribute to the progression of renal injury. In the present study, the urinary FN excretion (UFN) was measured for evaluation of its possible role as a prognostic marker in patients with newly diagnosed chronic glomerulonephritis (GN).
METHODS: In 55 patients with newly diagnosed biopsy-proven chronic GN, UFN was measured using an enzyme-immunossay kit. The progression of kidney disease was defined as a reduction of the estimated glomerular filtration rate (eGFR) >or=5 ml/min/year during the 4-year follow-up.
RESULTS: The mean UFN in patients with GN (245.0 +/- 229.2 ng/mmol creatinine) was higher than in the 19 healthy subjects (100.7 +/- 87.3 ng/mmol creatinine; p < 0.002). No correlations between the initial UFN and eGFR and proteinuria were found. We did not find any association between UFN and the severity of glomerular sclerosis or the intensity of interstitial fibrosis. The progressive fall of eGFR was recorded in 13 patients (progressors). The mean initial UFN was significantly higher in progressors than in nonprogressors (p < 0.01). In logistic regression analysis, the initial high UFN was identified as independent factor predicting kidney function deterioration.
CONCLUSION: These results indicate that UFN measured before treatment could serve as an additional prognostic marker of a poor outcome in patients with newly diagnosed primary GN.
Authors:
Ilona Idasiak-Piechocka; Andrzej Oko; Elzbieta Pawliczak; Elzbieta Kaczmarek; Stanisław Czekalski
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Publication Detail:
Type:  Journal Article     Date:  2010-05-12
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  116     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c47-52     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Transplantology and Internal Medicine, University of Medical Sciences, Poznań, Poland. ilonaidasiak@poczta.onet.pl
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