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Elevated Serum Levels of Soluble Axl in Acute Coronary Syndrome.
MedLine Citation:
PMID:  25474223     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND:: Morbidities related to atherosclerosis, such as acute coronary syndrome (ACS), remain the leading cause of mortality. Axl is a receptor tyrosine kinase that is expressed in mammalian vascular and immune cells. Axl signaling is involved in the regulation of the inflammatory response. A considerable amount of evidence indicates that inflammation is responsible for the development of atherosclerosis in patients with ACS.
METHODS:: To assess the relation of Axl and ACS, we recruited 64 patients with coronary heart disease: 34 with ACS, 30 with stable coronary heart disease, and 24 apparently healthy controls. Serum concentrations of soluble Axl (sAxl) were quantified by enzyme-linked immunosorbent assay. High-sensitivity C-reactive protein, tumor necrosis factor alpha, troponin I, and other routine biochemical markers were also measured.
RESULTS:: The levels of sAxl were significantly higher in patients with ACS than in the controls (P = 0.005). Furthermore, correlation analysis indicated that sAxl was significantly associated with serum levels of high-sensitivity C-reactive protein (r = 0.283, P = 0.008), tumor necrosis factor alpha (r = 0.565, P < 0.001), and troponin I (r = 0.264, P = 0.013). Logistic regression analysis (odds ratio = 1.038, 95% confidence interval, 1.008-1.069, P = 0.012) indicated a significant association between sAxl and ACS.
CONCLUSIONS:: Serum levels of sAxl correlate to inflammatory biochemical markers. These findings demonstrate for the first time that sAxl does have a role in ACS, presumably connected to the inflammation.
Authors:
Yu-Wei Liu; Qun-Fang Yang; Pei-Yuan Zuo; Chang-Liang Xiao; Xing-Lin Chen; Cheng-Yun Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-3
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  -     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-4     Completed Date:  -     Revised Date:  2014-12-5    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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