Document Detail

Elevated serum immunoglobulin G titers against Chlamydia pneumoniae in primary open-angle glaucoma patients without systemic disease.
MedLine Citation:
PMID:  20164795     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine if Chlamydia pneumoniae infection is associated with primary open-angle glaucoma (POAG).
PATIENTS AND METHODS: Consecutive patients with newly diagnosed primary POAG attending the Glaucoma clinic of Keio University Hospital between June 2007 and January 2008 were considered for inclusion in this prospective case-control study. Forty consecutive POAG patients and 41 normal healthy individuals as a control population met the inclusion criteria. The exclusion criteria for both groups were; taking steroids or immunosuppressive agents, smoking, and history of any acute or chronic systemic disease including stroke, heart attack, diabetes mellitus, hypertension, asthma, and autoimmune diseases. The serum was analyzed for C. pneumoniae and C. trachomatis immunoglobulin G antibody titers by enzyme-linked immunosorbent assay. Seroactivity to each antigen between case and control groups was evaluated by Mann-Whitney U test.
RESULTS: The age, male/female ratio, and intraocular pressure of the cases and control groups were not significantly different. Immunoglobulin G titers for C. pneuemoniae was significantly higher in patients with POAG than in controls (P=0.009). The titers to C. trachomatis were not significantly different between the 2 groups (P=0.99).
CONCLUSION: The results suggest that higher C. pneumoniae titers are associated with POAG. If confirmed, this may indicate either a common factor that causes susceptibilities to both glaucoma and C. pneumoniae infection or that C. pneumoniae may be a causal factor for developing POAG.
Kenya Yuki; Itaru Kimura; Daisuke Shiba; Yutaka Imamura; Kazuo Tsubota
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of glaucoma     Volume:  19     ISSN:  1536-481X     ISO Abbreviation:  J. Glaucoma     Publication Date:    2010 Oct-Nov
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-9     Citation Subset:  IM    
Department of Ophthalmology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
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MeSH Terms
Aged, 80 and over
Antibodies, Bacterial / blood*
Case-Control Studies
Chlamydia trachomatis / immunology
Chlamydophila Infections / immunology
Chlamydophila pneumoniae / immunology*
Enzyme-Linked Immunosorbent Assay
Glaucoma, Open-Angle / immunology*,  microbiology
Immunoglobulin G / blood*
Intraocular Pressure
Middle Aged
Prospective Studies
Risk Factors
Trachoma / immunology
Visual Acuity
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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