Document Detail

Elevated serum bone morphogenetic protein 4 in patients with chronic kidney disease and coronary artery disease.
MedLine Citation:
PMID:  23208015     Owner:  NLM     Status:  MEDLINE    
Chronic kidney disease (CKD) is associated with increased coronary artery disease (CAD) and coronary artery calcification. We hypothesized that the osteogenic factor, bone morphogenetic protein-4 (sBMP-4), is elevated in subjects with both CKD and CAD. Serum was collected from 79 subjects undergoing diagnostic angiography and stratified according to CAD and CKD status. Subjects with both CAD and CKD had significantly elevated sBMP-4 compared to those with only one or no disease. sBMP-4 continued to be associated with the presence of both diseases after adjustment for other risk factors. To determine if sBMP-4 is associated with coronary artery calcification, we compared coronary artery calcium scores (CAC) to sBMP-4 in 22 subjects. A positive correlation between CAC and sBMP-4 was seen. In conclusion, sBMP-4 is elevated in patients with both CAD and CKD and positively correlates with CAC, suggesting a role for sBMP-4 in the increased CAD seen in CKD patients.
Paul F Stahls; Daniel J Lightell; Stephanie C Moss; Corey K Goldman; T Cooper Woods
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-04
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  6     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-23     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-8     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Bone Morphogenetic Protein 4 / blood*
Chi-Square Distribution
Coronary Angiography / methods
Coronary Artery Disease / blood*,  etiology,  radiography
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Logistic Models
Middle Aged
Multidetector Computed Tomography
Multivariate Analysis
Pilot Projects
Renal Insufficiency, Chronic / blood*,  complications
Risk Factors
Vascular Calcification / blood*,  etiology,  radiography
Young Adult
Grant Support
5 P20 RR018766-10/RR/NCRR NIH HHS; 8 P20 GM103514-10/GM/NIGMS NIH HHS; P20 GM103514/GM/NIGMS NIH HHS; P20 RR018766/RR/NCRR NIH HHS
Reg. No./Substance:
0/BMP4 protein, human; 0/Biological Markers; 0/Bone Morphogenetic Protein 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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