Document Detail


Elevated pro-brain natriuretic Peptide, troponin T and malnutrition inflammatory score in chronic hemodialysis patients with overt cardiovascular disease.
MedLine Citation:
PMID:  20805692     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: We assessed the relationship between pro-brain natriuretic peptide (pro-BNP), troponin T (TropT) and nutritional status. Methods: A total of 48 chronic hemodialysis patients were grouped according to the presence [group A (GA); n = 24] or not [group B (GB)] of cardiovascular disease. Results: Compared to GB subjects, GA subjects were older, had been on hemodialysis for a longer period and had higher prevalences of vascular grafts, hypertension and elevated C-reactive protein (CRP) [GA vs. GB: 1.1 (range 0.1-32.9) vs. 0.4 (0-28.1) mg/dl; p = 0.028], malnutrition inflammatory score (MIS) (GA vs. GB: 7.50 vs. 4.00; p = 0.001), pro-BNP [GA vs. GB: 6,760 (601-103,200) vs. 686 (75-83,700) pg/ml; p < 0.001] and TropT [GA vs. GB: 0.3650 (0.011-0.199) vs. 0.010 (0.0-0.290) ng/ml; p = 0.002]. Pro-BNP correlated with TropT (rho 0.539; p < 0.001), MIS (rho 0.502; p < 0.0001), homocysteine (rho 0.321; p = 0.13) and CRP (rho 0.511; p < 0.0001). Pro-BNP levels were lower in GB patients as the body mass index increased; the opposite occurred in GA. Conclusions: Patients with cardiovascular disease had elevated pro-BNP and TropT levels. In patients without cardiovascular disease, malnutrition and inflammation were associated with vascular prostheses, while pro-BNP was lower in obese patients.
Authors:
Hernán Trimarchi; Alexis Muryan; Vicente Campolo-Girard; Mariana Dicugno; Nanci Barucca; Fernando Lombi; Pablo Young; Vanesa Pomeranz; Mariano Forrester; Mirta Alonso; Romina Iriarte; Marisa Luisa Díaz; Bengt Lindholm
Publication Detail:
Type:  Journal Article     Date:  2010-08-30
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  117     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c198-205     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Affiliation:
Servicio de Nefrología, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.
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