| Elevated plasma levels of chemerin in newly diagnosed type 2 diabetes mellitus with hypertension. | |
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MedLine Citation:
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PMID: 20601896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome. |
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Authors:
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Mengliu Yang; Gangyi Yang; Jing Dong; Ying Liu; Haihong Zong; Hua Liu; Guenther Boden; Ling Li |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of investigative medicine : the official publication of the American Federation for Clinical Research Volume: 58 ISSN: 1708-8267 ISO Abbreviation: J. Investig. Med. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501229 Medline TA: J Investig Med Country: Canada |
Other Details:
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Languages: eng Pagination: 883-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry and Key Laboratory of Laboratory Medical Diagnostics in Ministry of Education, Chongqing Medical University, Chongqing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology Body Composition / physiology Chemokines / blood* Diabetes Mellitus, Type 2 / diagnosis, metabolism* Female Hemoglobin A, Glycosylated / metabolism Humans Hypertension / diagnosis, metabolism* Insulin Resistance / physiology* Male Metabolic Syndrome X / diagnosis, metabolism* Middle Aged Obesity / diagnosis, metabolism Receptors, Chemokine / metabolism Waist Circumference / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01-DK 58895/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CMKLR1 protein, human; 0/Chemokines; 0/Hemoglobin A, Glycosylated; 0/Receptors, Chemokine; 0/chemerin, human; 0/hemoglobin A1c protein, human |
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