| Elevated Nε-(Carboxymethyl)lysine Is Associated with Apoptosis of Retinal Pericytes in Streptozotocin-Induced Diabetic Rats. | |
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MedLine Citation:
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PMID: 21273798 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Advanced glycation end products including Nε-(carboxymethyl)lysine (CML) are believed to contribute to retinal pericyte loss in diabetic retinopathy. Nuclear factor-κB (NF-κB) activation has been considered as a potential cytotoxic modulator of retinal pericytes. Herein, we investigated whether CML accumulation can trigger NF-κB activation and apoptosis of retinal pericytes in streptozotocin (STZ)-induced diabetic rats. Seven-week-old Sprague-Dawley rats were made diabetic (STZ, 60 mg/kg). After 5 months, CML level and NF-κB activation were measured in trypsin-digested retinal vessels. In diabetic rats, TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling)-positive and caspase 3-positive retinal pericytes were significantly increased. CML and NF-κB activation was also markedly increased in diabetic retinal vessels. Moreover, the immunoreactivity of NF-κB was localized within the region where CML were accumulated. Apoptosis occurred in CML-accumulating retinal pericytes. These results suggest that NF-κB could be activated in CML-accumulating pericytes from diabetic retina. CML accumulation is responsible, at least in part, for the apoptosis of retinal pericytes. |
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Authors:
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Junghyun Kim; Chan-Sik Kim; Eunjin Sohn; Jin Sook Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-27 |
Journal Detail:
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Title: Ophthalmic research Volume: 46 ISSN: 1423-0259 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: - |
Other Details:
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Languages: ENG Pagination: 92-97 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research Korea Institute of Oriental Medicine, Daejeon, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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