Document Detail


Elevated macrophage migration inhibitory factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol.
MedLine Citation:
PMID:  20382217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Macrophage Migration Inhibitory Factor (MIF) is a proinflammatory cytokine produced by leukocytes and the secretory cells of the HPA axis. Remarkably, glucocorticoids (GC) induce leukocyte MIF secretion, while MIF renders leukocytes insensitive to the anti-inflammatory effects of glucocorticoids. In light of reported associations between dysphoric states, increased inflammatory activity, and reduced GC sensitivity, the current study investigated the association between MIF, loneliness and depressive symptoms. The study further investigated the relation between plasma MIF and markers of HPA function, i.e., diurnal cortisol and the cortisol response to acute stress. Healthy university undergraduates (N=126; 64 women) were invited to participate if their scores on the Beck Depression Inventory or UCLA loneliness scale were in the upper or lower quintile of their peer group. Plasma MIF and salivary cortisol were measured in response to a public speaking task. Ambulatory diurnal cortisol was assessed for 5 consecutive days. MIF levels were 40% higher in the high-depressive symptoms group compared to the low depressive symptoms group. Elevated MIF was also associated with a smaller cortisol response to acute stress and lower diurnal morning cortisol values. The observed association between HPA function and MIF remained robust after adjustment for depressive symptoms, and demographic, anthropomorphic, and behavioural factors. High levels of depressive symptoms were likewise associated with lower morning cortisol, but this association became non-significant after adjustment for MIF. MIF may be an important neuro-immune mediator linking depressive symptoms with inflammation and HPA dysregulation.
Authors:
Kate M Edwards; Jos A Bosch; Christopher G Engeland; John T Cacioppo; Phillip T Marucha
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-09
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  24     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1202-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier Inc.
Affiliation:
Department of Psychiatry, UCSD Medical Center, University of California-San Diego, La Jolla, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Depression / blood,  metabolism*,  psychology*
Female
Humans
Hydrocortisone / metabolism*
Hypothalamo-Hypophyseal System / metabolism
Loneliness / psychology*
Macrophage Migration-Inhibitory Factors / blood*
Male
Neuropsychological Tests
Pituitary-Adrenal System / metabolism
Psychiatric Status Rating Scales
Saliva / metabolism
Speech
Stress, Psychological / complications,  metabolism*
Students
Time Factors
Universities
Young Adult
Grant Support
ID/Acronym/Agency:
P50 DE-13749/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Macrophage Migration-Inhibitory Factors; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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