| Elevated Levels of Uterine Anti-Apoptotic Signaling May Activate NFKB and Potentially Confer Resistance to Caspase 3-Mediated Apoptotic Cell Death During Pregnancy in Mice. | |
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MedLine Citation:
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PMID: 21566000 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preserving the uterus in a state of a relative quiescence is vital to the maintenance of a successful pregnancy. Elevated cytoplasmic levels of uterine caspase 3 during pregnancy have been proposed as a potential regulator of uterine quiescence through direct targeting and disabling of the uterine contractile architecture. However despite highly elevated levels of uterine caspase 3 during pregnancy there is minimal evidence of apoptosis. This current study defines the mechanism whereby the pregnant uterine myocyte may harness the tocolytic activity of active caspases while avoiding apoptotic cell death. Utilizing the pregnant mouse model we have analyzed the uterus for changes in pro and anti-apoptotic signaling patterns associated with the advancing stages of pregnancy. Briefly we have found that members of the IAP family such as SURVIVIN and XIAP and the Bcl2 family members such as MCL1 are elevated in the uterine myocyte during late gestation. The IAP family members are the only endogenous inhibitors of active caspase 3 and MCL1 limits activation of caspase 3 by suppressing pro-apoptotic signaling. Elevated XIAP levels partner with SURVIVIN resulting in increased levels of the anti-apoptotic MCL1 via NFKB activation, which together have the potential to limit both the activity and level of active caspase 3 in the pregnant uterus as term approaches. We propose that modification of these anti-apoptotic signaling partners allows the pregnant uterus to escape the apoptotic action of elevated active caspase 3 levels but also functions to limit the levels of active uterine caspase 3 towards term. |
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Authors:
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Pancharatnam Jeyasuria; Kalpana Subedi; Arvind Suresh; Jennifer Condon |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-12 |
Journal Detail:
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Title: Biology of reproduction Volume: - ISSN: 1529-7268 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207224 Medline TA: Biol Reprod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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