Document Detail


Elevated Levels of Coagulation Factor VIII in Patients With Venous Leg Ulcers.
MedLine Citation:
PMID:  24861090     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic venous disease affects millions of people around the world. Venous valvular incompetencies and venous reflux, often a result of outflow obstruction are important contributors to venous disease. The prevalence of thrombophilia is increased in patients with chronic venous insufficiency (CVI). The recognition of underlying thrombophilia particularly in young patients opens new avenues in the management and prevention plan. We emphasize on the consideration of workup for coagulopathy, especially factor VIII deficiency in young patients with venous disease. We report 3 patients with chronic leg ulcers and high levels of FVIII:C activity in plasma and other associated thrombophilic factors. We highlight the need to get a workup done for thrombophilia in young patients with recurrent and chronic leg ulcers related to venous insufficiency or livedoid vasculopathy. Further studies with larger sample sizes are required to define the definite indications for the thrombophilia workups.
Authors:
Paulo Ricardo Criado; Afsaneh Alavi; Robert S Kirsner
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-25
Journal Detail:
Title:  The international journal of lower extremity wounds     Volume:  -     ISSN:  1552-6941     ISO Abbreviation:  Int J Low Extrem Wounds     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128359     Medline TA:  Int J Low Extrem Wounds     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Author(s) 2014.
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