| Elevated levels of asymmetric dimethylarginine in chronic heart failure: a pathophysiologic link between oxygen radical load and impaired vasodilator capacity and the therapeutic effect of allopurinol. | |
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MedLine Citation:
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PMID: 20827268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide-dependent vasodilation. In 113 patients with chronic heart failure (CHF) and 26 controls, ADMA level was studied in relation to peripheral blood flow and vasodilator capacity. Further, the effects of allopurinol on concentrations of reactive oxygen species (ROS) and ADMA and peripheral vasodilator capacity were tested in a double-blind design. ADMA level was found to be elevated in CHF patients as compared with controls and increased in parallel with New York Heart Association (NYHA) class and exercise capacity (all P < 0.0001). The level of ADMA predicted resting blood flow (P < 0.05) and postischemic vasodilator capacity (P < 0.001). Sixty eight patients died during the follow-up period. The level of ADMA predicted survival after multivariable adjustment (P = 0.04). Allopurinol reduced uric acid (UA) concentration (P < 0.001) and decreased ROS concentration (allantoin, P < 0.01). Allopurinol lowered ADMA concentration (P = 0.02); postischemic vasodilation as well as endothelium-dependent vasodilation (both P < 0.05) improved. ADMA may be a pathophysiologic factor that is modulated by ROS accumulation and contributes to impaired vascular regulation in CHF. |
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Authors:
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S von Haehling; S M Bode-Böger; J Martens-Lobenhoffer; M Rauchhaus; J C Schefold; S Genth-Zotz; T Karhausen; M Cicoira; S D Anker; W Doehner |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-09-08 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 88 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 506-12 Citation Subset: AIM; IM |
Affiliation:
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Applied Cachexia Research, Department of Cardiology, Charité Medical School, Campus Virchow-Klinikum, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Allopurinol / pharmacology*, therapeutic use Arginine / analogs & derivatives*, blood Chronic Disease Citrulline / blood Cross-Sectional Studies Double-Blind Method Female Free Radical Scavengers / pharmacology*, therapeutic use Heart Failure / blood, physiopathology* Humans Male Middle Aged Reactive Oxygen Species / metabolism* Uric Acid / blood Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Reactive Oxygen Species; 0/dimethylarginine; 315-30-0/Allopurinol; 372-75-8/Citrulline; 69-93-2/Uric Acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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