Document Detail


Elevated expression of KiSS-1 in placenta of Chinese women with early-onset preeclampsia.
MedLine Citation:
PMID:  23145030     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preeclampsia (PE) is a heterogeneous syndrome affecting 2% to 8% of all pregnancies and is the world's leading cause of fetal and maternal morbidity and mortality. In many cases of PE, shallow trophoblast invasion results in inappropriate maternal spiral artery remodeling and impaired placental function. Multiple genes have been implicated in trophoblast invasion, among which are KiSS-1 and GPR54. The gene product of KiSS-1 is metastin, which is a ligand for the receptor GPR54. Both metastin and GPR54 are expressed in the placenta of normal pregnancy and have been implicated in modulating trophoblast invasion through inhibiting migration of trophoblast cells. We have previously reported that the expression level of KiSS-1 was higher in trophoblasts from women with preeclampsia as compared to normal controls. Here, using quantitative RT-PCR, Western blot analysis and immunohistochemistry, we extend our analysis to demonstrate that elevated KiSS-1 expression occurs only in early-onset preeclampsia (ePE) and not late-onset preeclampsia (lPE). However, no difference in the expression levels of GPR54 is observed between ePE, lPE, and normal controls. Further, we show that KiSS-1 expression is also increased in placenta of intrauterine death and birth asphyxia in comparison to normal newborns of ePE and lPE. Our findings suggest that aberrant upregulation of KiSS-1 expression may contribute to the underlying mechanism of ePE as well as birth asphyxia.
Authors:
Chong Qiao; Chunhui Wang; Jiao Zhao; Caixia Liu; Tao Shang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2013-07-24     Revised Date:  2014-02-13    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e48937     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Asphyxia Neonatorum / genetics,  metabolism
Female
Humans
Infant, Newborn
Kisspeptins / biosynthesis*,  genetics*,  metabolism
Placenta / metabolism*
Pre-Eclampsia / genetics*,  metabolism*,  pathology
Pregnancy
Pregnancy Complications / genetics,  metabolism
Receptors, G-Protein-Coupled / genetics,  metabolism
Trophoblasts / metabolism
Chemical
Reg. No./Substance:
0/KISS1 protein, human; 0/KISS1R protein, human; 0/Kisspeptins; 0/Receptors, G-Protein-Coupled
Comments/Corrections
Erratum In:
PLoS One. 2013;8(12). doi:10.1371/annotation/9887a53a-2b49-4172-8bc6-b63c85e06471

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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