| Elevated corticotropin releasing hormone (CRH) during pregnancy and risk of postpartum depression (PPD). | |
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MedLine Citation:
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PMID: 20943787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Perinatal depression has a prevalence of 10% with devastating consequences for mother and baby. The prospective identification of those at risk for postpartum (PPD) or prenatal (PND) depression has led to biomarker searches in pregnancy. There are conflicting reports of associations between midpregnancy placental CRH (pCRH) and PPD or PND. OBJECTIVE: The objective of the study was to quantify the association of maternal pCRH with PPD and PND. DESIGN: This was a prospective cohort study (the Pregnancy, Infection, and Nutrition Study). SETTING: The study was conducted at a prenatal clinics at the University of North Carolina at Chapel Hill. PATIENTS: Patients included 1230 pregnant women. MAIN OUTCOME MEASURES: The relationship between pCRH at less than 20 wk and 24-29 wk and maternal depression assessed in pregnancy [Center for Epidemiologic Studies Depression Scale (CES-D)] and postpartum (12 wk and 1 yr) with the Edinburgh Postnatal Depression Scale (EPDS). RESULTS: At 24-29 wk, 24.8% of women had CES-D score of 17 or greater, and 9.7% had a CES-D score of 25 or greater. At 12 wk postpartum, 18.2% of women had an EPDS score of 10 or greater and 7.6% had an EPDS score of 13 or greater. CRH measures at less than 20 wk and 24-29 wk were inversely correlated with a CES-D score at 24-29 wk (n = 1080, P < 0.05 and P < 0.01, respectively). Pregnancy pCRH was not correlated with the EPDS score at 12 wk (n = 484) or 1 yr postpartum (n = 391). In covariate-adjusted models, higher pCRH was not associated with a CES-D of 17 or greater at 24-29 wk (odds ratio 0.88 per sd change in pCRH at 24-29 wk, 95% confidence interval 0.76-1.03). There was no association between log CRH at 24-29 wk and PPD (covariate-adjusted odds ratio per sd 0.99, 95% confidence interval 0.69-1.42). CONCLUSION: Higher midpregnancy pCRH was not associated with an increased risk of PND or PPD. |
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Authors:
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Samantha Meltzer-Brody; Alison Stuebe; Nancy Dole; David Savitz; David Rubinow; John Thorp |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-13 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 96 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-06 Completed Date: 2011-02-04 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E40-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. meltzerb@med.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cohort Studies Corticotropin-Releasing Hormone / blood* Depression, Postpartum / blood*, etiology* Female Humans Immunoenzyme Techniques Linear Models Pregnancy Prospective Studies Psychiatric Status Rating Scales Risk |
| Grant Support | |
ID/Acronym/Agency:
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DK61981/DK/NIDDK NIH HHS; HD37584/HD/NICHD NIH HHS; HD3937/HD/NICHD NIH HHS; R24 HD050924-07/HD/NICHD NIH HHS; RR00046/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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