| Elevated Concentration of Asymmetric Dimethylarginine (ADMA) in Individuals with Metabolic Syndrome. | |
| | |
MedLine Citation:
|
PMID: 21419857 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The metabolic syndrome (MS) is a cluster of pathophysiological alterations that includes the presence of hypertension, insulin resistance, dyslipidemia, and abdominal obesity. MS is associated with increased risk of developing diabetes and cardiovascular diseases. Endothelial dysfunction with impaired nitric oxide (NO) bioavailability has been implicated in insulin resistance and hypertension. NO is synthesized by nitric oxide synthase (NOS) using L-arginine as substrate. Asymmetric dimethyl arginine (ADMA) is a major and potent endogenous NOS inhibitor, associated with cardiovascular and renal diseases. We tested the hypothesis that plasmatic ADMA levels are increased in patients with MS. We studied 85 adult individuals from Talca, Chile, separated in two groups, 48 individuals with MS (according to modified ATP III criteria), and 37 individuals without MS as controls. ADMA levels were significantly increased in the MS group (mean ± standard deviation 0.71 ± 0.38 vs. 0.48 ± 0.28 μmol/L, p=0.0009). Furthermore, the levels of ADMA were modestly but significantly correlated with waist circumference (p=0.01) but not with the other components of MS (blood pressure, glycemia, triglycerides and high density lipoprotein cholesterol HDL-c). These results suggest a possible link between increased ADMA levels and the MS. |
| | |
Authors:
|
Iván Palomo; Alejandra Contreras; L Marcelo Alarcón; Elba Leiva; Luis Guzmán; Verónica Mujica; Gloria Icaza; Nora Díaz; Daniel R González; Rodrigo Moore-Carrasco |
Related Documents
:
|
10720017 - Clinical review 112: does serum growth hormone (gh) binding protein reflect human gh re... 18602447 - Growth hormone signaling in pancreatic beta-cells--calcium handling regulated by growth... 17785697 - Metabolic implications of gh treatment in small for gestational age. 15461557 - The role of growth factors in the pathogenesis of diabetic retinopathy. 8606627 - The glucagonoma syndrome. clinical and pathologic features in 21 patients. 22382187 - Comparison of thrice daily biphasic human insulin (30/70) versus basal detemir & bolus ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
|
Title: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Volume: - ISSN: 1089-8611 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9709307 Medline TA: Nitric Oxide Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
|
Departamento de Bioquímica Clínica e Inmunohematología, Facultad de Ciencias de la Salud Universidad de Talca, Talca, Chile. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red bloo...
Next Document: The sphingosine-1-phosphate receptor agonist FTY720 dose dependently affected endothelial integrity ...