| Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value. | |
| | |
MedLine Citation:
|
PMID: 21126161 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Abstract TAR DNA binding protein of 43 kDa (TDP-43) is likely to be the major pathogenetic protein in amyotrophic lateral sclerosis (ALS). A previous study has shown that levels of TDP-43 in CSF measured by an ELISA are significantly higher for ALS patients than for controls. The aim of this study was to investigate whether elevated CSF TDP-43 levels are specific to ALS, and are associated with clinical profiles in ALS patients. We measured CSF TDP-43 levels by the same ELISA in 27 ALS patients and 50 neurodegenerative or inflammatory disease controls such as Parkinson's disease, multiple sclerosis, and Guillain-Barré syndrome. Results showed that the CSF TDP-43 levels were increased only in ALS patients. Receiver operating characteristic (ROC) analyses showed a sensitivity of 59.3% and a specificity of 96.0%. We also found that lower CSF TDP-43 levels may be associated with shorter survival time. In conclusion, the CSF TDP-43 is a potential biomarker that supports a diagnosis of ALS. Moreover, among ALS patients, lower levels of CSF TDP-43 may reflect the accumulation of TDP-43 in the cortical and spinal motor neurons and thereby shorter survival time, although this should be confirmed in larger prospective studies. |
| | |
Authors:
|
Yu-Ichi Noto; Kazumoto Shibuya; Yasunori Sato; Kazuaki Kanai; Sonoko Misawa; Setsu Sawai; Masahiro Mori; Tomoyuki Uchiyama; Sagiri Isose; Saiko Nasu; Yukari Sekiguchi; Yumi Fujimaki; Takashi Kasai; Takahiko Tokuda; Masanori Nakagawa; Satoshi Kuwabara |
Publication Detail:
|
Type: Journal Article Date: 2010-12-02 |
Journal Detail:
|
Title: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Volume: 12 ISSN: 1471-180X ISO Abbreviation: Amyotroph Lateral Scler Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101283386 Medline TA: Amyotroph Lateral Scler Country: England |
Other Details:
|
Languages: eng Pagination: 140-3 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hyperosmolar hyperglycemic state in advanced amyotrophic lateral sclerosis.
Next Document: Responding to the challenges of parenting a child with cerebral palsy: a focus group.