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Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value.
MedLine Citation:
PMID:  21126161     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract TAR DNA binding protein of 43 kDa (TDP-43) is likely to be the major pathogenetic protein in amyotrophic lateral sclerosis (ALS). A previous study has shown that levels of TDP-43 in CSF measured by an ELISA are significantly higher for ALS patients than for controls. The aim of this study was to investigate whether elevated CSF TDP-43 levels are specific to ALS, and are associated with clinical profiles in ALS patients. We measured CSF TDP-43 levels by the same ELISA in 27 ALS patients and 50 neurodegenerative or inflammatory disease controls such as Parkinson's disease, multiple sclerosis, and Guillain-Barré syndrome. Results showed that the CSF TDP-43 levels were increased only in ALS patients. Receiver operating characteristic (ROC) analyses showed a sensitivity of 59.3% and a specificity of 96.0%. We also found that lower CSF TDP-43 levels may be associated with shorter survival time. In conclusion, the CSF TDP-43 is a potential biomarker that supports a diagnosis of ALS. Moreover, among ALS patients, lower levels of CSF TDP-43 may reflect the accumulation of TDP-43 in the cortical and spinal motor neurons and thereby shorter survival time, although this should be confirmed in larger prospective studies.
Authors:
Yu-Ichi Noto; Kazumoto Shibuya; Yasunori Sato; Kazuaki Kanai; Sonoko Misawa; Setsu Sawai; Masahiro Mori; Tomoyuki Uchiyama; Sagiri Isose; Saiko Nasu; Yukari Sekiguchi; Yumi Fujimaki; Takashi Kasai; Takahiko Tokuda; Masanori Nakagawa; Satoshi Kuwabara
Publication Detail:
Type:  Journal Article     Date:  2010-12-02
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  12     ISSN:  1471-180X     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  IM    
Affiliation:
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba.
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