| Elevated CK-MB with normal total creatine kinase in suspected myocardial infarction: associated clinical findings and early prognosis. | |
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MedLine Citation:
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PMID: 3716977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that patients with normal serum levels of creatine kinase (CK) but elevated percentages of MB isoenzyme fractions in suspected myocardial infarction may have sustained clinically significant events, we studied the hospital course of 347 consecutive patients admitted with suspected myocardial infarction. Two hundred twenty-three patients had normal CK levels (182 +/- 44 IU) and normal MB percentages (normal group), 68 had elevated levels of both CK (1395 +/- 178 IU) and MB percentage (10.5 +/- 0.6) (macroinfarction group), and 40 had normal CK levels (96 +/- 7 IU) but elevated MB percentages (9.6 +/- 0.5) with typical enzyme curves (microinfarction group). Compared to the normal group, microinfarction patients were older, had more congestive heart failure, required more intensive monitoring and therapy during longer stays, and sustained a higher in-hospital mortality rate. Thus, these microinfarction patients are at increased risk and therefore warrant aggressive treatment and further evaluation. |
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Authors:
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R A Hong; J D Licht; J Y Wei; G V Heller; A S Blaustein; R C Pasternak |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American heart journal Volume: 111 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-06-27 Completed Date: 1986-06-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1041-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Creatine Kinase / blood* Female Humans Isoenzymes L-Lactate Dehydrogenase / blood Male Myocardial Infarction / enzymology*, mortality Prognosis Risk |
| Grant Support | |
ID/Acronym/Agency:
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HL29295/HL/NHLBI NIH HHS; RR-01032/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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