| Elevated CK-MB mass and plasma brain-type natriuretic peptide concentrations following convulsive seizures in children and adolescents: possible evidence of subtle cardiac dysfunction. | |
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MedLine Citation:
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PMID: 19183225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the presence of myocardial injury during convulsive seizures in children and adolescents by determining serum concentrations of cardiac troponin I (cTnI), creatine kinase-MB mass (CK-MB mass), and plasma brain-type natriuretic peptide (BNP). METHODS: Thirty-one children (20 boys; mean age, 6.6 +/- 5.34 years) with convulsive seizures and 50 healthy children were enrolled. Serum cTnI, CK-MB mass, and plasma BNP concentrations were analyzed 12 h after the seizure and repeated 7 days thereafter in the patient group and obtained one time in the control group. RESULTS: The difference between serum concentrations of cTnI obtained 12 h and 7 days after the seizure was not statistically significant. cTnI levels 12 h postictal and those in control subjects also were not significantly different. CK-MB mass and BNP at the 12th h were higher than those obtained on the 7th day (p < 0.05 and p < 0.001, respectively). Children with seizures had increased levels of CK-MB mass and BNP 12 h after seizure than control subjects (p < 0.05 and p < 0.001, respectively). The results of electrocardiography (ECG) recordings, which were obtained up to 30 min after seizure activity, were completely normal in patients with seizure. CONCLUSION: Normal cTnI levels are not indicative of overt myocardial necrosis in patients with seizures. However, markedly elevated BNP concentrations together with elevated CK-MB mass levels do suggest subtle cardiac dysfunction in patients with seizure, and further large-scale studies are warranted. |
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Authors:
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Füsun Alehan; Ilknur Erol; Tuba Cemil; Nilüfer Bayraktar; Ersin Ogüs; Kürsad Tokel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-06 |
Journal Detail:
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Title: Epilepsia Volume: 50 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-23 Completed Date: 2009-05-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 755-60 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Bahcelievler, Ankara, Turkey. falehan@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Creatine Kinase, MB Form / blood* Female Humans Immunoassay / methods Infant Male Natriuretic Peptide, Brain / blood* Retrospective Studies Seizures / blood* Statistics, Nonparametric Time Factors Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Troponin T; 114471-18-0/Natriuretic Peptide, Brain; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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