Document Detail

Elevated C-reactive protein: a common marker for atherosclerotic cardiovascular risk and subclinical stages of pulmonary dysfunction and osteopenia in a healthy population.
MedLine Citation:
PMID:  15585217     Owner:  NLM     Status:  MEDLINE    
Atherosclerotic cardiovascular disease, osteopenia, and pulmonary dysfunction are the serious health problems, and several experimental studies have suggested that inflammation has a role in them. The present study was conducted to evaluate the usefulness of the plasma CRP is as a common marker for detecting these diseases in the general population in their subclinical stages. In a cross-sectional study, we measured the pulse wave velocity (PWV), quantitative osteo-sono-assessment index (OSI), pulmonary functions, and the plasma level of C-reactive protein (CRP) in 7283 consecutive healthy subjects (age 50+/-11 years). The PWV was higher and the OSI and pulmonary function parameters were below normal in subjects with an elevated CRP level (> or =0.2 mg/dl) than in subjects with a CRP level within the normal range. We divided the subjects into quartiles for each of these parameters and found that the first quartiles represented patients with subclinical states of the aforementioned abnormal conditions. Logistic regression analysis demonstrated that the odds ratios of an elevated CRP level were individually significant in subjects with an elevated CRP level for each abnormality in women and for abnormal PWV and pulmonary dysfunction in men. In conclusion, in addition to being a marker of elevated atherosclerotic cardiovascular risk, elevated plasma CRP seems to be a marker of the early stages of osteopenia and pulmonary dysfunction in healthy subjects.
Hirofumi Tomiyama; Ryo Okazaki; Yutaka Koji; Yasuhiro Usui; Tsutomu Hayashi; Saburou Hori; Akira Yamashina
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  178     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
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MeSH Terms
Arteriosclerosis / diagnosis*,  etiology
Biological Markers / blood
Blood Flow Velocity
Bone Diseases, Metabolic / blood,  diagnosis*,  ultrasonography
C-Reactive Protein / metabolism*
Cohort Studies
Cross-Sectional Studies
Early Diagnosis
Logistic Models
Lung Diseases / blood,  diagnosis*,  ultrasonography
Mass Screening*
Middle Aged
Respiratory Function Tests
Risk Factors
Sex Factors
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

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