Document Detail

Elevated brain natriuretic peptide is associated with abnormal heart geometry in children with chronic kidney disease.
MedLine Citation:
PMID:  20234137     Owner:  NLM     Status:  MEDLINE    
AIM: It was to establish whether brain natriuretic peptide (BNP) might predict cardiac dysfunction in children with chronic kidney disease (CKD). METHODS: The relation between BNP, echocardiography and risk factors (hypertension, anemia, lipids, CRP, hyperparathyroidism) was investigated in 46 children (10 pre-dialysis patients, 14 on dialysis, 11 children with kidney transplants, and 11 healthy controls). Data on BNP were transformed into common logarithms (log(10) BNP, log BNP). RESULTS: log BNP was significantly higher in dialysis patients when compared to controls (2.09 +/- 0.78 vs. 1.43 +/- 0.34 pg/ml, p = 0.012) and patients in the pre-dialysis stage (2.09 +/- 0.78 vs. 1.52 +/- 0.42 pg/ml, p = 0.039). log BNP in transplanted children was not significantly different from healthy children (2.09 +/- 0.78 vs. 1.71 +/- 0.46 pg/ml, p = 0.19). Abnormal heart geometry (concentric and eccentric hypertrophy, concentric remodeling) was found in 19 patients (54.28%). A significant correlation was observed between log BNP and ventricular hypertrophy (r = 0.515, p = 0.001). Compared to controls higher log BNP was seen in children with eccentric hypertrophy than in children with concentric hypertrophy (2.178 +/- 0.956 vs. 1.496 +/- 0.395 pg/ml, p = 0.05, or 1.982 +/- 0.618 vs. 1.496 +/- 0.395, p = 0.04). CONCLUSIONS: BNP might predict an abnormal geometry in children with CKD.
J Hedvig; L Podracká; D Potoceková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-16
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  33     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-04     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Pediatrics, Medical Faculty UPJS and DFN, Kosice, Slovak Republic.
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MeSH Terms
Biological Markers / blood
Cardiomegaly / blood,  diagnosis*,  etiology,  ultrasonography
Cardiovascular Diseases / diagnosis,  etiology
Case-Control Studies
Chronic Disease
Hypertrophy, Left Ventricular
Kidney Diseases / complications*
Natriuretic Peptide, Brain / blood*
Predictive Value of Tests
Risk Factors
Young Adult
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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