| Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. | |
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MedLine Citation:
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PMID: 20150769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have suggested that autophagy plays a pivotal role in regulation of cancer development and progression. High expression of the autophagy-related Beclin 1 protein predicted favorable patient outcome in several tumors. Here, a randomized controlled trial (RCT)-derived 128 nasopharyngeal carcinoma (NPC) patients were subjected to analysis of Beclin 1 expression and survival probability. In this RCT, 61 patients treated with induction chemotherapy plus concurrent chemoradiotherapy were used as a training set to generate a Beclin 1 cutoff score for patient outcome by receiver operating characteristic (ROC) curve analysis. For validation, the ROC-derived cutoff point was subjected to analysis of the association of Beclin 1 expression with patient outcome and clinical characteristics in testing set. The testing set comprised of 67 patients received induction chemotherapy plus radiotherapy. In the testing set and overall patients, our univariate and multivariate analysis showed that higher Beclin 1 expression, defined by the training set ROC analysis-generated cutoff score, predicted poorer overall survival, progression-free survival and distant metastasis-free survival. However, we failed to detect a correlation between Beclin 1 and local failure-free survival. Moreover, a positive relationship between Beclin 1 and HI F-1alpha expression was found. Importantly, among patients with elevated HI F-1alpha expression, a subset with lower Beclin 1 expression displayed a significant overall survival advantage than those with higher expression (p = 0.036). Contrary to previous studies, our results demonstrated that high autophagic Beclin 1 expression was an inferior prognostic marker for NPC. HI F-1alpha-associated Beclin 1 high expression might facilitate NPC cells surviving from chemoradiotherapy, suggesting a novel therapeutic molecular target for NPC. |
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Authors:
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Xiang-Bo Wan; Xin-Juan Fan; Ming-Yuan Chen; Jin Xiang; Pei-Yu Huang; Ling Guo; Xiang-Yuan Wu; Jie Xu; Zi-Jie Long; Yan Zhao; Wei-Hua Zhou; Hai-Qiang Mai; Quentin Liu; Ming-Huang Hong |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-04-26 |
Journal Detail:
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Title: Autophagy Volume: 6 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 395-404 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antineoplastic Agents / therapeutic use Apoptosis Regulatory Proteins / metabolism* Combined Modality Therapy Female Humans Hypoxia-Inducible Factor 1, alpha Subunit / metabolism* Kaplan-Meiers Estimate Male Membrane Proteins / metabolism* Nasopharyngeal Neoplasms / diagnosis*, drug therapy, metabolism*, radiotherapy Prognosis Proportional Hazards Models ROC Curve Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Apoptosis Regulatory Proteins; 0/BECN1 protein, human; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Membrane Proteins |
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