| Elevated amniotic fluid stromal cell-derived factor-1alpha (SDF-1alpha) concentration in mid-gestation as a predictor of adverse birth outcomes. | |
| | |
MedLine Citation:
|
PMID: 20028644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: This study aimed to predict maternal and neonatal outcomes by measuring mid-trimester amniotic fluid stromal cell-derived factor-1alpha (SDF-1alpha) concentration in healthy women. METHODS: Mid-trimester amniotic fluid samples from healthy women with a singleton pregnancy were obtained at the time of genetic amniocenteses. SDF-1alpha concentrations were determined by enzyme-linked immunosorbent assay. Maternal and neonatal characteristics were recorded. RESULTS: A total of 210 samples were collected. According to the SDF-1alpha cutoff value established by the receiver operating characteristic curve analysis (< 6.42 vs. > or = 6.42 pg/mL), there was a trend toward higher preterm birth rate, lower birth weight and lower 1-minute and 5-minute Apgar scores when SDF-1alpha levels increased (p < 0.05). The pair comparison between normal and selected pregnancy disorders (gestational diabetes, pre-eclampsia, and abnormal placentation) showed no statistical significance (p > 0.05). Pearson's correlations of SDF-1alpha to gestational age at delivery (r = -0.151) and birth weight (r = -0.194) were significant (p < 0.05). In the multivariate analysis on mid-trimester SDF-1alpha levels, maternal age at sampling (regression coefficient = -0.163) and 1-minute Apgar score (< 7 vs. > or = 7, regression coefficient = 2.028) were both significant (p < 0.05). CONCLUSION: Increased SDF-1alpha levels in mid-trimester amniotic fluid suggest a possible role in predicting pregnant women at risk of adverse neonatal outcomes including higher preterm birth rate, lower birth weight, and lower Apgar scores. |
| | |
Authors:
|
Jenn-Jhy Tseng; Ya-Fang Chen; Yeun-Ting Hsieh; Min-Min Chou |
Related Documents
:
|
15576824 - Polyamine synthesis from proline in the developing porcine placenta. 15791664 - Prenatal diagnosis of megacystis-microcolon-intestinal hypoperistalsis syndrome: contri... 16236364 - Clara cell protein 16 concentration in mid-trimester amniotic fluid: association with f... 18776724 - Increased fetal plasma and amniotic fluid erythropoietin concentrations: markers of int... 19175964 - Cervix length and relaxin as predictors of preterm birth. 16229884 - Comparison of synchronization of ovulation with timed insemination and exogenous proges... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the Chinese Medical Association : JCMA Volume: 72 ISSN: 1728-7731 ISO Abbreviation: J Chin Med Assoc Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-23 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101174817 Medline TA: J Chin Med Assoc Country: China (Republic : 1949- ) |
Other Details:
|
Languages: eng Pagination: 638-42 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C. t1018@vghtc.gov.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amniotic Fluid / chemistry* Apgar Score Chemokine CXCL12 / analysis*, physiology Chromosome Aberrations Female Humans Infant, Low Birth Weight Infant, Newborn Multivariate Analysis Pregnancy Premature Birth |
| Chemical | |
Reg. No./Substance:
|
0/Chemokine CXCL12 |
| Comments/Corrections | |
Comment In:
|
J Chin Med Assoc. 2009 Dec;72(12):617-8
[PMID:
20028639
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Initial Clinical Experience with Surgical Technique of Robot-assisted Transperitoneal Laparoscopic P...
Next Document: A Cardiac Pseudo-tumor Associated with Pseudo-infarction Electrocardiographic Pattern.