Document Detail


Elevated acetoacetate and monocyte chemotactic protein-1 levels in cord blood of infants of diabetic mothers.
MedLine Citation:
PMID:  22776897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Infants of diabetic mothers (IDMs) are at increased risk for metabolic complications. Type 1 and some type 2 diabetic patients have elevated levels of the ketone bodies acetoacetate (AA) and β-hydroxybutyrate (BHB).
OBJECTIVE: The aim of this study was to examine how hyperketonemia in diabetic mothers affects markers of inflammation and oxidative stress in their offspring.
METHODS: Blood was obtained from 23 diabetic mothers and 13 healthy mothers and their infants' umbilical cords at delivery. Interleukin-8, monocyte chemotactic protein-1 (MCP-1) and protein carbonyl (protein oxidation) levels were determined by ELISA. U937 human monocyte cell culture was used to examine the effect of AA and BHB on secretion of MCP-1.
RESULTS: There was a significant increase in the levels of AA in cord blood of IDMs compared with cord blood of infants of healthy mothers. A significant increase in the levels of protein oxidation (p < 0.05) and MCP-1 levels (p < 0.05) was observed in the cord blood of IDMs. The level of MCP-1 correlated significantly (r = 0.51, p = 0.01) with the concentration of AA in the IDMs. In further experiments with cultured monocytes treated with exogenous AA (0-4 mM), a significant increase in MCP-1 secretion was observed in AA- but not BHB-treated monocytes.
CONCLUSION: Blood levels of AA and MCP-1 are elevated in IDMs, which may contribute to the development of the metabolic complications seen in IDMs.
Authors:
Dalibor Kurepa; Arun K Pramanik; Venkatakrishna Kakkilaya; Gloria Caldito; Lynn J Groome; Joseph A Bocchini; Sushil K Jain
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-04
Journal Detail:
Title:  Neonatology     Volume:  102     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-25     Completed Date:  2013-02-25     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Departments of Pediatrics and Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetoacetates / analysis,  blood*,  metabolism
Adult
Case-Control Studies
Chemokine CCL2 / analysis,  blood*,  metabolism
Diabetes Mellitus, Type 1 / blood,  metabolism
Diabetes, Gestational / blood,  metabolism
Female
Fetal Blood / chemistry*,  metabolism
Humans
Infant, Newborn / blood*,  metabolism
Pregnancy
Pregnancy in Diabetics* / blood,  metabolism
Prenatal Exposure Delayed Effects / blood,  metabolism
U937 Cells
Up-Regulation
Young Adult
Grant Support
ID/Acronym/Agency:
R01 DK072433/DK/NIDDK NIH HHS; R01 DK072433/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Acetoacetates; 0/Chemokine CCL2; 541-50-4/acetoacetic acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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