Document Detail


Elevated 1,25(OH)2D3, intestinal absorption, and renal mineral conservation in male rats.
MedLine Citation:
PMID:  6546474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the physiological importance of elevated serum 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] in male rats. Male and female rats of equal weight consumed either a high calcium diet (1.20% calcium; HCD), a low calcium diet (0.02% calcium; LCD), or a normal calcium diet (0.60% calcium; NCD). With all three diets, serum 1,25(OH)2D3 was higher in males than females and rose in both sexes with decreasing diet calcium. There was a direct correlation between serum 1,25(OH)2D3 and proximal duodenal 45Ca uptake (r = 0.667; P less than 0.001). With NCD, we performed a balance study and found a direct correlation between serum 1,25(OH)2D3 and both 5-day fractional calcium absorption (r = 0.703; P less than 0.01) and fractional phosphorus absorption (r = 0.679; P less than 0.01). In addition, serum 1,25(OH)2D3 was directly correlated with 5-day calcium retention (r = 0.772; P less than 0.001) and phosphorus retention (r = 0.830; P less than 0.001). Males grew faster than females (F ratio = 1,194; P less than 0.001). Elevated 1,25(OH)2D3 in males appears to be of biological significance and may help satisfy a greater, growth-related, need for calcium.
Authors:
D A Bushinsky; M J Favus; F L Coe
Related Documents :
10981544 - Factors affecting blood pressure responses to diet: the vanguard study.
6273514 - Renal acid, urinary cyclic amp, and hydroxyproline excretion as affected by level of pr...
12449294 - Effect of yogurt on a urinary marker of bone resorption in postmenopausal women.
15578454 - Nutrient intake and urine composition in calcium oxalate stone-forming dogs: comparison...
1637794 - Influence of gender, body mass index, and age on response of plasma lipids to dietary f...
10757624 - Dietary restraint in normal weight and overweight children. a cross-sectional study.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  246     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-14     Completed Date:  1984-03-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  F140-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Blood Chemical Analysis
Calcitriol / blood*,  metabolism
Calcium / metabolism
Female
Intestines / metabolism*
Kidney / metabolism*
Male
Minerals / metabolism*
Rats / growth & development,  physiology*
Rats, Inbred Strains
Urine / analysis
Grant Support
ID/Acronym/Agency:
AM-20585/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Minerals; 32222-06-3/Calcitriol; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differing effects of hydroxy-7-oxotaurine-conjugated bile acids on bile flow and biliary lipid secre...
Next Document:  AIDS surveillance and health education: use of previously described risk factors to identify high-ri...