Document Detail

Elements of a paracrine tubular renin-angiotensin system along the entire nephron.
MedLine Citation:
PMID:  10601129     Owner:  NLM     Status:  MEDLINE    
The renin-angiotensin system is a major regulator of body sodium, predominantly through the actions of intrarenal angiotensin II of unclear origin. We show that polarized epithelium of the proximal tubule synthesizes and secretes angiotensinogen at its apical side and that the protein can be detected in urine as a function of dietary sodium. Furthermore, we demonstrate that renin is expressed and secreted in a restricted nephron segment, the connecting tubule, also in a sodium-dependent fashion. A paracrine renin-angiotensin system operating along the entire nephron may contribute to long-term arterial pressure regulation by integrating distant tubular sodium-reabsorbing functions.
A Rohrwasser; T Morgan; H F Dillon; L Zhao; C W Callaway; E Hillas; S Zhang; T Cheng; T Inagami; K Ward; D A Terreros; J M Lalouel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  34     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-19     Completed Date:  2000-01-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1265-74     Citation Subset:  IM    
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, USA.
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MeSH Terms
Angiotensinogen / secretion
Blotting, Western
CHO Cells
Cell Line
Diuretics / pharmacology
Epithelial Cells / metabolism
Immune Sera / metabolism
Juxtaglomerular Apparatus / drug effects,  metabolism
Kidney Tubules, Proximal / cytology,  drug effects,  metabolism,  physiology*
Mice, Inbred C57BL
Nephrons / cytology,  metabolism,  physiology*
Paracrine Communication / physiology*
Renin / biosynthesis,  immunology
Renin-Angiotensin System / physiology*
Reverse Transcriptase Polymerase Chain Reaction
Sodium, Dietary / pharmacology
Grant Support
Reg. No./Substance:
0/Diuretics; 0/Immune Sera; 0/Sodium, Dietary; 11002-13-4/Angiotensinogen; EC

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