| Elemental diets in the repair of small intestinal damage. | |
| | |
MedLine Citation:
|
PMID: 9263283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have investigated the possible benefits of elemental diets, especially a diet supplemented with L-glutamine, on maintenance of intestinal absorptive function in rat small intestine damaged by 5-fluorouracil. Although a standard rat diet sustained better body growth in control rats, each of the elemental diets and the diet containing intact casein in place of hydrolyzed casein was beneficial in promoting less body weight loss during the 3 d after 5-fluorouracil injection. The same significant benefit was seen in absorptive activity measured in small intestine in vitro 3 d after the cytotoxic injury. Glutamine supplementation, however, did not confer any significant advantages, although it did cause significant elevation of muscle glutamine pools. This elevation was substantially less than the corresponding increase in muscle glycine content after dietary supplementation with glycine. |
| | |
Authors:
|
M L Gardner; S D Earl; D Wood |
Related Documents
:
|
8067613 - Effects of dietary supplementation of fructo-oligosaccharides on small intestinal bacte... 12755303 - Dimensions and histologic characteristics of the small intestine of dogs during postnat... 12970903 - Effects of low-calorie diet on steatohepatitis in rats with obesity and hyperlipidemia. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 13 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 1997 Jul-Aug |
Date Detail:
|
Created Date: 1998-04-21 Completed Date: 1998-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8802712 Medline TA: Nutrition Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 755-9 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Sciences, University of Bradford, West Yorkshire, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antimetabolites / administration & dosage Body Weight Caseins / administration & dosage Cohort Studies Diet* Fluorouracil / administration & dosage Food, Formulated* Glutamine / administration & dosage*, therapeutic use Glycine / administration & dosage Intestinal Absorption / drug effects, physiology* Intestine, Small / metabolism* Male Rats |
| Chemical | |
Reg. No./Substance:
|
0/Antimetabolites; 0/Caseins; 51-21-8/Fluorouracil; 56-40-6/Glycine; 56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outcome of critically ill patients after supplementation with glutamine.
Next Document: The Bridgeport Hospital experience with autologous transfusion in orthopedic surgery.