Document Detail

Electrostatic charging during a melt agglomeration process.
MedLine Citation:
PMID:  10425354     Owner:  NLM     Status:  MEDLINE    
Lactose monohydrate was melt agglomerated in an 8-l high shear mixer using stearic acid, polyethylene glycol (PEG) 3000, and a mixture of stearic acid and glycerol monostearate as meltable binders. Electrostatic charging during processing at relative air humidities of 35 and 75%, respectively, was estimated from the voltage of a monitoring probe inserted into the mixer. Stearic acid produced a high level of electrostatic charges, whereas PEG 3000 gave rise to a markedly lower level. Addition of glycerol monostearate to the stearic acid reduced the level of electrostatic charges. A correlation was found between the resistivity of the binder and the level of electrostatic charges in the material. With the stearic acid and the binder mixture, the level of electrostatic charges was higher at a low air humidity. The amount of adhesion to the bowl was found to depend on the level of electrostatic charges.
H Eliasen; H G Kristensen; T Schaefer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  184     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2010-06-25    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  85-96     Citation Subset:  IM    
Copyright Information:
The Royal Danish School of Pharmacy, Department of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark.
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MeSH Terms
Chemistry, Pharmaceutical / methods*
Chemistry, Physical
Excipients / chemistry*
Glycerides / chemistry
Lactose / chemistry
Physicochemical Phenomena
Polyethylene Glycols / chemistry
Static Electricity
Stearic Acids / chemistry
Reg. No./Substance:
0/Excipients; 0/Glycerides; 0/Polyethylene Glycols; 0/Stearic Acids; 31566-31-1/glyceryl monostearate; 57-11-4/stearic acid; 63-42-3/Lactose

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