| Electrospun silk biomaterial scaffolds for regenerative medicine. | |
| | |
MedLine Citation:
|
PMID: 19643154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electrospinning is a versatile technique that enables the development of nanofiber-based biomaterial scaffolds. Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix in tissues. Silk is a natural protein with excellent biocompatibility, remarkable mechanical properties as well as tailorable degradability. Integrating these protein polymer advantages with electrospinning results in scaffolds with combined biochemical, topographical and mechanical cues with versatility for a range of biomaterial, cell and tissue studies and applications. This review covers research related to electrospinning of silk, including process parameters, post treatment of the spun fibers, functionalization of nanofibers, and the potential applications for these material systems in regenerative medicine. Research challenges and future trends are also discussed. |
| | |
Authors:
|
Xiaohui Zhang; Michaela R Reagan; David L Kaplan |
Related Documents
:
|
21495704 - Effect of organic and conventional crop rotation, fertilization, and crop protection pr... 21431444 - Changes in public commons as a consequence of urbanization: the agara lake in bangalore... 17202964 - Effective employee counseling for the first-line health care manager. 16271814 - Regulating manure application discharges from concentrated animal feeding operations in... 16841174 - Distorting gene pools by conservation: assessing the case of doomed turtle eggs. 19380984 - Managing terminology assets in electronic health records. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2009-07-28 |
Journal Detail:
|
Title: Advanced drug delivery reviews Volume: 61 ISSN: 1872-8294 ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-05 Completed Date: 2010-03-05 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 988-1006 Citation Subset: IM |
Affiliation:
|
Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biomimetic Materials
/
chemistry*,
therapeutic use Biomimetics / instrumentation*, methods Electrochemistry Nanofibers / chemistry Regenerative Medicine* Silk / chemistry* Tissue Engineering / instrumentation, methods* Tissue Scaffolds / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
|
P41 EB002520-06A1S1/EB/NIBIB NIH HHS; R01 DE017207-03/DE/NIDCR NIH HHS; R01 EB003210-07/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Silk |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery.
Next Document: Electrospinning of polysaccharides for regenerative medicine.