Document Detail

Electrospun fibers of acid-labile biodegradable polymers with acetal groups as potential drug carriers.
MedLine Citation:
PMID:  18571349     Owner:  NLM     Status:  MEDLINE    
The local delivery and controllable release profiles make electrospun ultrafine fibers as potential implantable drug carriers and functional coatings of medical devices. Till date there is no literature report on drug delivery from acid-labile electrospun fibers, whose degradation and drug release behaviors respond to the local pathological pH environment. Acid-labile groups have been incorporated into nonbiodegradable backbones as crosslinkers or linkers of the side chains. A novel strategy was developed in this study to synthesize acid-labile polymers by introducing acetal groups into biodegradable backbone of poly(dl-lactide)-poly(ethylene glycol). In vitro release study showed that the total amount of drug released from acid-labile polymeric fibers was accelerated on account of pH-induced structural and morphological changes of fibrous mats and the degradation of matrix polymers, and the burst release was significant higher for polymers with higher contents of acid-labile segments. During the investigational period, almost no molecular weight reduction and mass loss was detected in neutral buffer solutions, but the degradation was enhanced in acid buffers with a two-stage degradation profile. Surface erosion mechanism was initially detected for fibrous mats with distinct fiber morphologies, and bulk degradation was determined during the following incubation for polymeric films resulting from the morphological changes.
Wenguo Cui; Mingbo Qi; Xiaohong Li; Shaozhou Huang; Shaobing Zhou; Jie Weng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-15
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  361     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-10-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  47-55     Citation Subset:  IM    
Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China.
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MeSH Terms
Acetaminophen / chemistry
Chemistry, Pharmaceutical
Cross-Linking Reagents / chemistry
Delayed-Action Preparations
Drug Carriers / chemistry*
Drug Implants
Hydrogen-Ion Concentration
Lactates / chemistry*
Molecular Weight
Polyethylene Glycols / chemistry*
Static Electricity
Technology, Pharmaceutical / methods*
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Delayed-Action Preparations; 0/Drug Carriers; 0/Drug Implants; 0/Lactates; 0/Polyethylene Glycols; 0/poly(lactic acid-ethylene glycol); 103-90-2/Acetaminophen

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