Document Detail


Electrospun biocomposite nanofibrous patch for cardiac tissue engineering.
MedLine Citation:
PMID:  21813957     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A bioengineered construct that matches the chemical, mechanical, biological properties and extracellular matrix morphology of native tissue could be suitable as a cardiac patch for supporting the heart after myocardial infarction. The potential of utilizing a composite nanofibrous scaffold of poly(dl-lactide-co-glycolide)/gelatin (PLGA/Gel) as a biomimetic cardiac patch is studied by culturing a population of cardiomyocyte containing cells on the electrospun scaffolds. The chemical characterization and mechanical properties of the electrospun PLGA and PLGA/Gel nanofibers were studied by Fourier transform infrared spectroscopy, scanning electron microscopy and tensile measurements. The biocompatibility of the scaffolds was also studied and the cardiomyocytes seeded on PLGA/Gel nanofibers were found to express the typical functional cardiac proteins such as alpha-actinin and troponin I, showing the easy integration of cardiomyocytes on PLGA/Gel scaffolds. Our studies strengthen the application of electrospun PLGA/Gel nanofibers as a bio-mechanical support for injured myocardium and as a potential substrate for induction of endogenous cardiomyocyte proliferation, ultimately reducing the cardiac dysfunction and improving cardiac remodeling.
Authors:
Molamma P Prabhakaran; Dan Kai; Laleh Ghasemi-Mobarakeh; Seeram Ramakrishna
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-03
Journal Detail:
Title:  Biomedical materials (Bristol, England)     Volume:  6     ISSN:  1748-605X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101285195     Medline TA:  Biomed Mater     Country:  -    
Other Details:
Languages:  ENG     Pagination:  055001     Citation Subset:  -    
Affiliation:
Health Care and Energy Materials Laboratory, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576.
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