| Electrosprayed synthesis of red-blood-cell-like particles with dual modality for magnetic resonance and fluorescence imaging. | |
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MedLine Citation:
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PMID: 20878793 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Red blood cells (RBCs) are able to avoid filtration in the spleen to prolong their half-time in the body because of their flexibility and unique shape, or a concave disk with diameter of some 10 μm. In addition, they can flow through capillary blood vessels, which are smaller than the diameter of RBCs, by morphing into a parachute-like shape. In this study, flexible RBC-like polymer particles are synthesized by electrospraying based on electrospinning. Furthermore, magnetite nanoparticles and fluorescent dye are encapsulated in the particles via in situ hydrolysis of an iron-organic compound in the presence of celluloses. The superparamagnetic behavior of the particles is confirmed by low-temperature magnetic measurements. The particles exhibited not only a dark contrast in magnetic resonance imaging (MRI), but also effective fluorescence. The RBC-like particles with flexibility are demonstrated to have a dual-modality for MRI and fluorescence imaging. |
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Authors:
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Koichiro Hayashi; Kenji Ono; Hiromi Suzuki; Makoto Sawada; Makoto Moriya; Wataru Sakamoto; Toshinobu Yogo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Small (Weinheim an der Bergstrasse, Germany) Volume: 6 ISSN: 1613-6829 ISO Abbreviation: Small Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235338 Medline TA: Small Country: Germany |
Other Details:
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Languages: eng Pagination: 2384-91 Citation Subset: IM |
Affiliation:
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Division of Nanomaterials Science, EcoTopia Science Institute, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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