Document Detail


Electrospray tandem mass spectrometric analysis of novel synthetic quinoxalinone derivatives.
MedLine Citation:
PMID:  18286668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrospray ionization tandem mass spectrometry (ESI-MS/MS) using a hybrid QqToF-MS/MS instrument has aided the structural characterization and differentiation of a novel series of medicinal synthetic 1-N-glycoside-quinoxalinone derivatives. These derivatives 7 and 8 are formed by an amino bond between the cyclic N-1 of the quinoxaline moiety and the C-6 position of a fully protected methyl or allyl alpha-D-mannofuranoside 3 and 4, and subsequent deprotection of the mannopyranoside moiety. In general the novel synthetic quinoxaline derivatives afforded the protonated molecules in ESI. The breakdown routes of the protonated molecules were rationalized by conducting low-energy CID-MS/MS analyses. In addition, re-confirmation of the various established fragmentation routes was achieved by conducting a series of ESI-CID-QqTof-MS/MS product ion scans on various selected precursor ions, which were initiated by CID in the atmospheric pressure/vacuum interface using a higher declustering potential. ESI-QqToF-MS/MS analysis has proven to be a specific and very sensitive method for the structural identification in the gas phase of these novel glycoquinoxalinamine derivatives.
Authors:
Nicolas Joly; Chakir Jarmoumi; Mohamed Massoui; El Mokhtar Essassi; Patrick Martin; Joseph H Banoub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  22     ISSN:  0951-4198     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  819-33     Citation Subset:  IM    
Affiliation:
Laboratoire de Physico-Chimie des Interfaces et Applications FRE CNRS 2485, Fédération Chevreul FR CNRS 2638, Site de Béthune, IUT de Béthune BP819, 62408 Béthune, France.
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MeSH Terms
Descriptor/Qualifier:
Quinoxalines / chemistry*
Reproducibility of Results
Sensitivity and Specificity
Spectrometry, Mass, Electrospray Ionization / methods*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
Chemical
Reg. No./Substance:
0/Quinoxalines

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