| Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly(lactic acid) for bone regeneration. | |
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MedLine Citation:
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PMID: 16826596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Development of fibrous matrices of bioceramic-biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. However, in order to produce electrospun fibers with homogeneous structure, it is essential for the ceramic powder to be fine and to remain stable in suspension. Herein, we developed a novel method whereby the bioceramic hydroxyapatite (HA) was kept in suspension in biopolymer poly(lactic acid) (PLA). The strategy was to introduce a surfactant hydroxysteric acid (HSA) between the hydrophilic HA powder and the hydrophobic chloroform-dissolved PLA. The HA nanopowder was dispersed effectively in HSA and mixed homogeneously with PLA. Continuous and uniform fibers were generated successfully with diameters of approximately 1-2 microm, and featured a well-developed nanocomposite structure of HA nanopowder-dispersed PLA. Initial cellular assays showed excellent cell attachment and proliferation and also enhanced expression of alkaline phosphatase at 7 days of culturing. The HA-PLA nanocomposite fibers may be potentially useful in tissue engineering applications, particularly as three-dimensional substrates for bone growth. |
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Authors:
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Hae-Won Kim; Hae-Hyoung Lee; J C Knowles |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 79 ISSN: 1549-3296 ISO Abbreviation: - Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-10-24 Completed Date: 2007-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 643-9 Citation Subset: IM |
Affiliation:
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Department of Dental Biomaterials, School of Dentistry, Dankook University, Cheonan 330-714, Korea. kimhw@dku.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Regeneration
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drug effects* Cell Line Durapatite / chemistry*, pharmacology* Electrons* Humans Lactic Acid / chemistry* Microscopy, Electron, Scanning Microscopy, Electron, Transmission Nanocomposites / chemistry*, ultrastructure* Osteoblasts / drug effects Polymers / chemistry* Solutions |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 0/Solutions; 1306-06-5/Durapatite; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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