Document Detail

Electrospinning approaches toward scaffold engineering--a brief overview.
MedLine Citation:
PMID:  17026578     Owner:  NLM     Status:  MEDLINE    
Tissue engineering involves the in vitro seeding of cells onto scaffolds which assume the role of supporting cell adhesion, migration, proliferation, and differentiation, and which define the three-dimensional shape of the tissue to be engineered. Among the various types of scaffold architectures available, scaffolds based on nanofibers mimicking to a certain extent the structure of the extracellular matrix offer great advantages. Electrospinning is the technique of choice for the preparation of such scaffolds. Investigations have revealed that the nanofibrous structure promotes cell adhesion, proliferation, and differentiation. Parameters relevant for these processes such as fiber diameters, surface topology, porosity, mechanical properties, and the fibrous architecture of the scaffold can be controlled by electrospinning in a broad range.
Ulrich Boudriot; Roland Dersch; Andreas Greiner; Joachim H Wendorff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Artificial organs     Volume:  30     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  785-92     Citation Subset:  IM    
Department of Orthopaedic Surgery, Philipps-University, Marburg, Germany.
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MeSH Terms
Biocompatible Materials
Cell Adhesion
Cell Differentiation
Cell Movement
Cells, Cultured
Electromagnetic Fields
Nanotechnology / methods*
Tissue Engineering / methods*
Reg. No./Substance:
0/Biocompatible Materials; 0/Polymers

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