Document Detail

Electroretinographic findings in transplant chorioretinopathy.
MedLine Citation:
PMID:  20689794     Owner:  NLM     Status:  PubMed-not-MEDLINE    
AIM: Transplant chorioretinopathy is a rare complication following solid organ or bone marrow transplantation and can result in severe vision loss. This series presents electroretinogram (ERG) results in patients with this condition.
METHODS: Patients who presented with bilateral vision loss following bone marrow or solid organ transplantation were identified. A complete ophthalmologic examination, fundus photography, and fluorescein angiography (FA) were performed. Full-field ERG was obtained in all patients and a multifocal ERG (mfERG) was obtained in two patients.
RESULTS: Four patients were identified. All patients had bilateral vision loss and displayed a characteristic pattern of mottled hyperfluorescence on FA. Three patients developed progressive vision loss ranging from 20/60 to hand motions whereas one retained 20/40 vision. All patients exhibited moderate to severe cone dysfunction, while the degree of rod abnormalities was varied. Two patients with severe cone dysfunction showed mild clinical changes initially, but later developed progressive vision loss and chorioretinal atrophy.
CONCLUSION: Transplant chorioretinopathy patients undergoing ERG testing show cone dysfunction with a variable degree of rod dysfunction. ERG abnormalities preceded the visual acuity and clinical changes in two patients, suggesting that ERG may be a helpful predictor of the clinical course in this rare disease.
Brian T Chan-Kai; Steven Yeh; Richard G Weleber; Peter J Francis; Grazyna Adamus; S Robert Witherspoon; Andreas K Lauer
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Publication Detail:
Type:  Journal Article     Date:  2010-07-30
Journal Detail:
Title:  Clinical ophthalmology (Auckland, N.Z.)     Volume:  4     ISSN:  1177-5483     ISO Abbreviation:  Clin Ophthalmol     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-06     Completed Date:  2011-06-29     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101321512     Medline TA:  Clin Ophthalmol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  777-83     Citation Subset:  -    
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas.
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