| Electroporation of the heart. | |
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MedLine Citation:
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PMID: 16102512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defibrillation shocks are commonly used to terminate life-threatening arrhythmias. According to the excitation theory of defibrillation, such shocks are aimed at depolarizing the membranes of most cardiac cells resulting in resynchronization of electrical activity in the heart. If shock-induced changes in transmembrane potential are large enough, they can cause transient tissue damage due to electroporation. In this review evidence is presented that (a) electroporation of the heart tissue can occur during clinically relevant intensities of the external electrical field, and (b) electroporation can affect the outcome of defibrillation therapy; being both pro- and anti-arrhythmic. |
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Authors:
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Vladimir P Nikolski; Igor R Efimov |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 7 Suppl 2 ISSN: 1099-5129 ISO Abbreviation: Europace Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-16 Completed Date: 2005-12-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
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Languages: eng Pagination: 146-54 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coloring Agents Electroporation* Electroshock / adverse effects* Heart* Heart Conduction System / physiopathology Humans Membrane Potentials / physiology Optics and Photonics Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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R01HL-074283/HL/NHLBI NIH HHS; R01HL-67322/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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