| Electrophysiology of mammalian Schwann cells. | |
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MedLine Citation:
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PMID: 12429109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Schwann cells are the satellite cell of the peripheral nervous system, and they surround axons and motor nerve terminals. The review summarises evidence for the ion channels expressed by mammalian Schwann cells, their molecular nature and known or speculated functions. In addition, the recent evidence for gap junctions and cytoplasmic diffusion pathways within the myelin and the functional consequences of a lower-resistance myelin sheath are discussed. The main types of ion channel expressed by Schwann cells are K(+) channels, Cl(-) channels, Na(+) channels and Ca(2+) channels. Each is represented by a variety of sub-types. The molecular and biophysical characteristics of the cation channels expressed by Schwann cells are closely similar or identical to those of channels expressed in peripheral axons and elsewhere. In addition, Schwann cells express P(2)X ligand-gated ion channels. Possible in vivo roles for each ion channel type are discussed. Ion channel expression in culture could have a special function in driving or controlling cell proliferation and recent evidence indicates that some Ca(2+) channel and Kir channel expression in culture is dependent upon the presence of neurones and local electrical activity. |
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Authors:
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Mark D Baker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Progress in biophysics and molecular biology Volume: 78 ISSN: 0079-6107 ISO Abbreviation: Prog. Biophys. Mol. Biol. Publication Date: 2002 Feb-Apr |
Date Detail:
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Created Date: 2002-11-13 Completed Date: 2002-12-20 Revised Date: 2010-01-14 |
Medline Journal Info:
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Nlm Unique ID: 0401233 Medline TA: Prog Biophys Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 83-103 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ltd. |
Affiliation:
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Molecular Nociception Group, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK. mark.baker@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anions / metabolism Electrophysiology Humans Myelin Sheath / metabolism Potassium / metabolism Potassium Channels / metabolism Receptors, Purinergic P2 / metabolism Schwann Cells / metabolism, physiology* Sodium Channels / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anions; 0/Potassium Channels; 0/Receptors, Purinergic P2; 0/Sodium Channels; 0/purinergic P2X receptor; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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