| Electrophysiology of the chemically sympathectomised dog. | |
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MedLine Citation:
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PMID: 6816469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contribution of the sympathetic nervous system in the definition of various electrophysiological variables was studied in chemically sympathectomised dogs. Chemical sympathectomy was obtained following intravenous injection of 50 mg X kg-1 of 6-hydroxydopamine. Sympathectomised dogs presented significant increases in: basic sinus period, sino-atrial conduction time (SACT), AH and HV intervals of the His bundle electrogram, atrial functional (AFRP) and effective (AERP) refractory periods, atrio-ventricular node functional (AVNFRP) and effective (AVNERP) refractory periods, ventricular functional (VFRP) and effective (EVRP) refractory periods and atrial (AMAP) and ventricular (VMAP) monophasic action potential durations. Corrected sinus recovery time (CSRT) was not affected by chemical sympathectomy. Neither was the atrial ERP/MAP duration ratio. This new form of sympathectomy affects all the levels of the cardiac conduction system. Such results are in accordance with those obtained with surgical sympathectomy or the use of beta-blocking agents. |
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Authors:
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D Godin; C Guimond; R A Nadeau; A R Leblanc |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 16 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1983-02-25 Completed Date: 1983-02-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 524-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Function Dogs Electrophysiology Heart / physiology* Heart Conduction System / physiology Hydroxydopamines Oxidopamine Sympathectomy, Chemical* Sympathetic Nervous System / physiology Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/Hydroxydopamines; 1199-18-4/Oxidopamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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