Document Detail

Electrophysiological study of infant and adult rats under acute intoxication with fluoroacetamide.
MedLine Citation:
PMID:  17351914     Owner:  NLM     Status:  MEDLINE    
A study was conducted of acute intoxication of infant and adult Wistar rats with fluoroacetamide (FAA), an inhibitor of oxidative metabolism. FAA was administered orally to adult rats at 1/2 LD(50) and subcutaneously to infant rats at LD(100) or 1/10 LD(50). Electrocardiogram (ECG), respiration and motor activity were registered for 7 days. Clinical analysis of ECG and the heart rate variability (HRV) was carried out to assess the state of the vegetative nervous system. In adult rats, FAA caused marked disturbances in the activity of cardiovascular and respiratory systems, including the development of a potentially lethal acute cor pulmonale. Conversely, there were no significant changes of cardiac function and respiration in infant rats; they died because of extreme emaciation accompanied by retardation of development. In adult rats, bursts of associated cardiac and respiratory tachyarrhythmia, as well as regular high amplitude spasmodic sighs having a deca-second rhythm were observed. In both infant and adult rats, FAA caused short-term enhancement of humoral (metabolic) and sympathetic activities, followed by a gradual and stable predominance of parasympathetic influence on HRV. Under conditions of FAA inhibition of the tricarboxylic acid cycle, the observed physiological reactions may be explained by activation of alternative metabolic pathways. This is also supported by a lack of ontogenetically caused inhibition of spontaneous motor activity in infant rats poisoned with FAA, which highlights the significance of the alternative metabolic pathways for implementation of deca-second and minute rhythms and a lack of a rigid dependence of these rhythms upon activity of neuronal networks.
Sergey V Kuznetsov; Richard O Jenkins; Nikolay V Goncharov
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  27     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-10-30     Completed Date:  2007-12-13     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  538-50     Citation Subset:  IM    
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, St Petersburg, Russia.
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MeSH Terms
Acute Disease
Acute Toxicity Tests
Administration, Oral
Age Factors
Animals, Newborn
Arrhythmias, Cardiac / chemically induced,  physiopathology
Dose-Response Relationship, Drug
Energy Metabolism / drug effects
Enzyme Inhibitors / administration & dosage,  toxicity*
Fluoroacetates / administration & dosage,  toxicity*
Heart / drug effects*,  innervation
Heart Rate / drug effects*
Injections, Subcutaneous
Motor Activity / drug effects*
Parasympathetic Nervous System / drug effects,  physiopathology
Pulmonary Heart Disease / chemically induced,  physiopathology
Rats, Wistar
Respiration / drug effects*
Sympathetic Nervous System / drug effects,  physiopathology
Time Factors
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Fluoroacetates; 640-19-7/fluoroacetamide

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