Document Detail


Electrophysiological studies of salty taste modification by organic acids in the labellar taste cell of the blowfly.
MedLine Citation:
PMID:  11751469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using the labellar salt receptor cells of the blowfly, Phormia regina, we electrophysiologically showed that the response to NaCl and KCl aqueous solutions was enhanced and depressed by acetic, succinic and citric acids. The organic acid concentrations at which the most enhanced salt response (MESR) was obtained were found to be different: 0.05-1 mM citric acid, 0.5-2 mM succinic acid and 5-50 mM acetic acid. Moreover, the degree of the salt response was not always dependent on the pH values of the stimulating solutions. The salt response was also enhanced by HCl (pH 3.5-3.0) only when the NaCl concentration was greater than the threshold, indicating that the salty taste would be enhanced by the comparatively lower concentrations of hydrogen ions. Another explanation for the enhancement is that the salty taste may also be enhanced by undissociated molecules of the organic acids, because the MESRs were obtained at the pH values lower than the pKa(1) or pKa(2) values of these organic acids. On the other hand, the salty taste could be depressed by both the lower pH range (pH 2.5-2.0) and the dissociated organic anions from organic acid molecules with at least two carboxyl groups.
Authors:
Yoshihiro Murata; Naoko Kataoka-Shirasugi; Taisaku Amakawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical senses     Volume:  27     ISSN:  0379-864X     ISO Abbreviation:  Chem. Senses     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2003-03-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  57-65     Citation Subset:  IM    
Affiliation:
Department of Life Science, Graduate School of Science and Technology, Kobe University, Kobe 657-8501, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carboxylic Acids / pharmacology*
Chemoreceptor Cells / drug effects,  physiology
Diptera / physiology*
Discrimination (Psychology)
Dose-Response Relationship, Drug
Electrophysiology / methods*
Hydrogen-Ion Concentration
Perception
Potassium Chloride / pharmacology*
Sodium Chloride / pharmacology*
Taste / drug effects*
Chemical
Reg. No./Substance:
0/Carboxylic Acids; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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