Document Detail


Electrophysiological studies on rabbits in long-term exposure to carbon disulfide.
MedLine Citation:
PMID:  1228898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electroneuromyography was performed as part of a multidemensional study of experimental carbon disulfide poisoning of rabbits. Ten rabbits were exposed by inhalation of 750 ppm of carbon disulfide for 6 hours a day, 5 days a week for 10 weeks. A slowing of the motor conduction velocity of the sciatic nerve was clearly observable during the course of exposure. This slowing preceded clinical paralysis, which became severe in the hind limbs within 9 weeks. Although the amplitude of the motor response to stimulation diminished markedly towards the end of the exposure period, a response of about 2 mV was always elicitable. Definite fibrillations could be noted in the gastrocnemius muscle of the rabbits after exposure for 9 weeks. In the two rabbits allowed to recover, the fibrillations continued for up to 2 months after the cessation of the carbon disulfide exposure. As the paralysis was very severe, even though the nervous conductivity was rather well preserved, it was assumed that a lesion at the spinal cord level was combined with neuropathy. These experimental findings from rabbits agreed well with results from clinical studies of workers occupationally exposed to carbon disulfide. Some similarities, but also differences, were observable between neurophysiological findings in carbon disulfide and other forms of experimental toxic neuropathy.
Authors:
A M Seppäläinen; I Linnoila
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  1     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  178-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Disulfide / toxicity*
Electromyography
Electrophysiology
Environmental Exposure
Muscle Contraction / drug effects*
Neural Conduction / drug effects*
Neuromuscular Diseases / chemically induced
Paralysis / chemically induced*
Rabbits
Sciatic Nerve / physiology
Chemical
Reg. No./Substance:
75-15-0/Carbon Disulfide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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