| Electrophysiological studies on rabbits in long-term exposure to carbon disulfide. | |
| | |
MedLine Citation:
|
PMID: 1228898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electroneuromyography was performed as part of a multidemensional study of experimental carbon disulfide poisoning of rabbits. Ten rabbits were exposed by inhalation of 750 ppm of carbon disulfide for 6 hours a day, 5 days a week for 10 weeks. A slowing of the motor conduction velocity of the sciatic nerve was clearly observable during the course of exposure. This slowing preceded clinical paralysis, which became severe in the hind limbs within 9 weeks. Although the amplitude of the motor response to stimulation diminished markedly towards the end of the exposure period, a response of about 2 mV was always elicitable. Definite fibrillations could be noted in the gastrocnemius muscle of the rabbits after exposure for 9 weeks. In the two rabbits allowed to recover, the fibrillations continued for up to 2 months after the cessation of the carbon disulfide exposure. As the paralysis was very severe, even though the nervous conductivity was rather well preserved, it was assumed that a lesion at the spinal cord level was combined with neuropathy. These experimental findings from rabbits agreed well with results from clinical studies of workers occupationally exposed to carbon disulfide. Some similarities, but also differences, were observable between neurophysiological findings in carbon disulfide and other forms of experimental toxic neuropathy. |
| | |
Authors:
|
A M Seppäläinen; I Linnoila |
Related Documents
:
|
3377548 - Acute respiratory effects of short-term exposures to nitrogen dioxide. 10655138 - Intrascleral concentration vs depth profile of mitomycin-c after episcleral application... 12706398 - Anguilla anguilla l. liver ethoxyresorufin o-deethylation, glutathione s-transferase, e... 18391218 - Massive global ozone loss predicted following regional nuclear conflict. 8901468 - Effects of hypoxia, simulated ischemia and reoxygenation on the contractile function of... 19908058 - The effects of progressive dehydration on strength and power: is there a dose response? |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Scandinavian journal of work, environment & health Volume: 1 ISSN: 0355-3140 ISO Abbreviation: Scand J Work Environ Health Publication Date: 1975 Sep |
Date Detail:
|
Created Date: 1976-09-01 Completed Date: 1976-09-01 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7511540 Medline TA: Scand J Work Environ Health Country: FINLAND |
Other Details:
|
Languages: eng Pagination: 178-83 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Disulfide / toxicity* Electromyography Electrophysiology Environmental Exposure Muscle Contraction / drug effects* Neural Conduction / drug effects* Neuromuscular Diseases / chemically induced Paralysis / chemically induced* Rabbits Sciatic Nerve / physiology |
| Chemical | |
Reg. No./Substance:
|
75-15-0/Carbon Disulfide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Occupational lead exposure in Finland. IV. The polyvinyl chloride plastic industry.
Next Document: Determination of toxic metals in blood by x-ray fluorescence spectrometry.