| Electrophysiological and pharmacological properties of the pulmonary vein myocardium. | |
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MedLine Citation:
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PMID: 23302630 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The pulmonary vein contains a myocardial layer extending from the left atrium, which is receiving attention as the source of ectopic electrical activity underlying atrial fibrillation. Electrophysiological and pharmacological analysis of the pulmonary vein myocardium performed in various experimental animal species have revealed characteristics such as presence of intracellular Ca(2+) oscillations and low repolarizing potency. The automaticity of the pulmonary vein myocardium is affected by various neurotransmitters, hormones and pharmacological agents. Clarification of the mechanisms and regulation of pulmonary vein automaticity would lead to the development of novel therapeutic strategies and pharmacological agents for atrial fibrillation. |
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Authors:
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Iyuki Namekata; Yayoi Tsuneoka; Hikaru Tanaka |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 36 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 2-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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