Document Detail

Electrophysiological and morphological development of the inner ear in Belgian Waterslager canaries.
MedLine Citation:
PMID:  20638464     Owner:  NLM     Status:  MEDLINE    
Belgian Waterslager (BW) canaries have an inherited hearing loss due to missing and abnormal hair cells, but it is unclear whether the loss is congenital or developmental. We used auditory brainstem responses and scanning electron microscopy to describe the development of auditory sensitivity and hair cell abnormalities in BW and non-BW canaries. In both strains, adult ABR thresholds were higher than behavioral thresholds, but BW canaries exhibited higher thresholds than non-BW canaries across all frequencies. Immediately post-hatch, ABR thresholds and hair cell numbers were similar in both strains. Two weeks later, thresholds were significantly higher in BW canaries, and hair cell number progressively decreased as the birds aged. These data show that in BW canaries: the peripheral auditory system is functionally similar to non-BW canary from hatch to 2 weeks, ABR thresholds improve during this developmental period, actually becoming better than those of adults, but then worsen as the bird continues to age. Hair cell number and appearance is similar to non-BW canaries at hatch but progressively declines after 30 days of age. These data show that the hearing loss characteristic of BW canaries is, at least in part, developmental and is established by the time song learning begins.
Elizabeth F Brittan-Powell; Robert J Dooling; Brenda Ryals; Otto Gleich
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-16
Journal Detail:
Title:  Hearing research     Volume:  269     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-28     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  56-69     Citation Subset:  IM    
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MeSH Terms
Acoustic Stimulation
Aging / pathology,  physiology*
Auditory Threshold / physiology
Canaries / growth & development*,  physiology*
Ear, Inner / growth & development*,  physiopathology*
Electrophysiological Phenomena / physiology*
Evoked Potentials, Auditory, Brain Stem / physiology
Hair Cells, Auditory, Inner / pathology,  physiology,  ultrastructure
Hearing Loss / physiopathology*
Microscopy, Electron, Scanning
Models, Animal
Reaction Time / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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