Document Detail

Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis-, reperfusion- and reoxygenation-induced arrhythmias.
MedLine Citation:
PMID:  4075017     Owner:  NLM     Status:  MEDLINE    
The antiarrhythmic potency of mexiletine was evaluated on three groups of guinea-pig isolated hearts. Arrhythmias were induced (a) with digitalis intoxication, (b) with hypoxia followed by reoxygenation and (c) with ischaemia followed by reperfusion. Mexiletine 10 microM was found to be very effective against all three types of arrhythmias in all three groups. The electrophysiological effects of mexiletine were then studied on sheep cardiac Purkinje fibres manifesting oscillatory afterpotentials and triggered automaticity induced by barium or strophanthidin. Mexiletine 10 microM consistently decreased the amplitude of oscillatory afterpotentials and blocked subsequent triggered activity in sheep Purkinje fibres. In contrast, mexiletine 10 microM had no significant effect on Vmax in normal, barium- and strophanthidin-treated preparations. The results are discussed in relation to the mechanisms of antiarrhythmic action of mexiletine.
S Amerini; P Carbonin; E Cerbai; A Giotti; A Mugelli; M Pahor
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  86     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-02-12     Completed Date:  1986-02-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  805-15     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Arrhythmias, Cardiac / etiology,  physiopathology*
Barium / antagonists & inhibitors
Coronary Circulation
Depression, Chemical
Guinea Pigs
Heart Conduction System / drug effects*
Heart Ventricles / drug effects
Medigoxin / antagonists & inhibitors
Mexiletine / pharmacology*
Myocardial Contraction / drug effects*
Oxygen / physiology
Propylamines / pharmacology*
Purkinje Fibers / drug effects
Strophanthidin / antagonists & inhibitors
Reg. No./Substance:
0/Propylamines; 30685-43-9/Medigoxin; 31828-71-4/Mexiletine; 66-28-4/Strophanthidin; 7440-39-3/Barium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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