Document Detail

Electrophysiological evidence for the autoregulation of beta-cell secretion by insulin.
MedLine Citation:
PMID:  322725     Owner:  NLM     Status:  MEDLINE    
Electrophysiological studies of cultured rat pancreatic beta-cells using intracellular microelectrodes show that exogenous insulin over the range of 0.1 -- 10.0 microng/ml inhibits the electrical activity due to 27.8 mM glucose in a dose-related manner. This inhibitory effect is manifested by a mean increase of the membrane potential from about --20 to --30 mV and inhibition of the number of cells impaled showing spike activity from 60 to less than 10%. The inhibitory influence of insulin is rapid occurring within 5 min for the highest level used. The results provide evidence for a negative feedback role of insulin in regulating its own release.
C S Pace; F M Matschinsky; P E Lacy; S Conant
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  497     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  408-14     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Electric Conductivity
Glucose / pharmacology
Insulin / pharmacology,  secretion*
Islets of Langerhans / drug effects,  physiology,  secretion*
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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