Document Detail

Electrophysiological evaluation of central and peripheral neural effects of lead exposure.
MedLine Citation:
PMID:  6097849     Owner:  NLM     Status:  MEDLINE    
Lead encephalopathy is more usual in children and has rarely been observed in adults. Peripheral neuropathy on the other hand is of more common occurrence among adults with occupational lead exposure, and has been extensively studied with electrophysiological methods. Although encephalopathy often manifests itself with generalized seizures, usual electroencephalographic (EEG) findings have been diffuse slow wave abnormalities. Paroxysmal abnormalities either focal or generalized spikes and/or sharp waves have been detected in some patients. Evoked potential studies have lately been applied to children or adults with a relatively low level of lead exposure, and minor dose-dependent differences have appeared in comparison to control groups. Subclinical signs of peripheral neuropathy have been detected among human subjects with various levels of lead exposure. Nerve conduction velocities of lead workers have been generally lower, although the means have been within normal limits. Some authors have shown clear correlations between measures of lead exposure and nerve conduction velocities indicating an exposure--effect relationship.
A M Seppäläinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  5     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1984  
Date Detail:
Created Date:  1985-03-05     Completed Date:  1985-03-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  IM    
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MeSH Terms
Central Nervous System Diseases / chemically induced
Evoked Potentials
Lead Poisoning / complications,  diagnosis*
Neural Conduction
Occupational Diseases / chemically induced
Peripheral Nervous System Diseases / chemically induced

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