| Electrophysiological effects of propranolol in patients with sinus node dysfunction. | |
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MedLine Citation:
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PMID: 3172475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The electrophysiological effects of intravenous propranolol (0.15 mg/kg) were studied in 26 patients with sinus node dysfunction (SND group) and 9 patients with normal sinus node function (control group). Spontaneous cycle length and AH interval were significantly increased in the control and SND groups after propranolol. PA and HV intervals, calculated sinoatrial conduction time and refractory periods of the atrium, AV node and ventricle were not significantly changed in either group. Maximum corrected sinus node recovery time (max CSRT) was not changed in the control group, but it was significantly prolonged in the SND group. These results of the overdrive suppression test were in disagreement with those of previous studies. Propranolol lengthened spontaneous cycle length (by more than 200 msec) and/or max CSRT (by more than 1000 msec) in 8 of 26 patients with SND. Thus, it is suggested that propranolol should be used with caution in patients with SND. |
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Authors:
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Y Tsuchioka; K Matsumoto; H Fujii; S Masaoka; A Yuasa; H Tateishi; H Matsuura; H Sato; G Kajiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 29 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-11-10 Completed Date: 1988-11-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Hiroshima University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmia, Sinus
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physiopathology* Arrhythmias, Cardiac / physiopathology* Bradycardia / physiopathology Electrocardiography Electrophysiology Female Heart Conduction System / drug effects* Humans Male Middle Aged Propranolol / pharmacology* Refractory Period, Electrophysiological / drug effects Sinoatrial Block / physiopathology Tachycardia, Supraventricular / physiopathology |
| Chemical | |
Reg. No./Substance:
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525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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