Document Detail

Electrophysiological effects of propranolol in patients with sinus node dysfunction.
MedLine Citation:
PMID:  3172475     Owner:  NLM     Status:  MEDLINE    
The electrophysiological effects of intravenous propranolol (0.15 mg/kg) were studied in 26 patients with sinus node dysfunction (SND group) and 9 patients with normal sinus node function (control group). Spontaneous cycle length and AH interval were significantly increased in the control and SND groups after propranolol. PA and HV intervals, calculated sinoatrial conduction time and refractory periods of the atrium, AV node and ventricle were not significantly changed in either group. Maximum corrected sinus node recovery time (max CSRT) was not changed in the control group, but it was significantly prolonged in the SND group. These results of the overdrive suppression test were in disagreement with those of previous studies. Propranolol lengthened spontaneous cycle length (by more than 200 msec) and/or max CSRT (by more than 1000 msec) in 8 of 26 patients with SND. Thus, it is suggested that propranolol should be used with caution in patients with SND.
Y Tsuchioka; K Matsumoto; H Fujii; S Masaoka; A Yuasa; H Tateishi; H Matsuura; H Sato; G Kajiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  29     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-11-10     Completed Date:  1988-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM    
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Arrhythmia, Sinus / physiopathology*
Arrhythmias, Cardiac / physiopathology*
Bradycardia / physiopathology
Heart Conduction System / drug effects*
Middle Aged
Propranolol / pharmacology*
Refractory Period, Electrophysiological / drug effects
Sinoatrial Block / physiopathology
Tachycardia, Supraventricular / physiopathology
Reg. No./Substance:

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