| Electrophysiological effects of melperone in the dog heart in situ - a new antiarrhythmic drug. | |
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MedLine Citation:
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PMID: 6114796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In pentobarbital anaesthetised dogs, melperone (a neuroleptic butyrophenone) reduced mean aortic blood pressure and at lower doses (0.5 and 2.5 mg . kg-1) increased the heart rate. By means of His bundle electrography and programmed electrical stimulation, conduction velocity and refractoriness were measured at different frequencies of stimulation (170, 200, 230 and 260 beats.min-1). Melperone 0.5 and 2.5 mg.kg-1 decreased the atrioventricular nodal conduction time and refractoriness. Melperone (0.5 to 12.5 mg.kg-1) did not affect the intra-atrial or His-Purkinje conduction times or the QRS width. However, melperone increased the functional and effective refractory period of the right atrium and ventricle dose-dependently at all frequencies studied. This suggests that melperone may be a valuable drug in treating selected cardiac arrhythmias. |
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Authors:
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H Refsum; J P Amlie; E S Platou; T Owren; K Landmark |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 15 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-10-29 Completed Date: 1981-10-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / pharmacology* Antipsychotic Agents / pharmacology* Blood Pressure / drug effects Butyrophenones / pharmacology* Dogs Electric Stimulation Electrocardiography Heart / drug effects, physiology* Heart Conduction System / drug effects, physiology Heart Rate / drug effects Male |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Antipsychotic Agents; 0/Butyrophenones; 3575-80-2/metylperon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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