Document Detail


Electrophysiological effects of melperone in the dog heart in situ - a new antiarrhythmic drug.
MedLine Citation:
PMID:  6114796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In pentobarbital anaesthetised dogs, melperone (a neuroleptic butyrophenone) reduced mean aortic blood pressure and at lower doses (0.5 and 2.5 mg . kg-1) increased the heart rate. By means of His bundle electrography and programmed electrical stimulation, conduction velocity and refractoriness were measured at different frequencies of stimulation (170, 200, 230 and 260 beats.min-1). Melperone 0.5 and 2.5 mg.kg-1 decreased the atrioventricular nodal conduction time and refractoriness. Melperone (0.5 to 12.5 mg.kg-1) did not affect the intra-atrial or His-Purkinje conduction times or the QRS width. However, melperone increased the functional and effective refractory period of the right atrium and ventricle dose-dependently at all frequencies studied. This suggests that melperone may be a valuable drug in treating selected cardiac arrhythmias.
Authors:
H Refsum; J P Amlie; E S Platou; T Owren; K Landmark
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  15     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-10-29     Completed Date:  1981-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents / pharmacology*
Antipsychotic Agents / pharmacology*
Blood Pressure / drug effects
Butyrophenones / pharmacology*
Dogs
Electric Stimulation
Electrocardiography
Heart / drug effects,  physiology*
Heart Conduction System / drug effects,  physiology
Heart Rate / drug effects
Male
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Antipsychotic Agents; 0/Butyrophenones; 3575-80-2/metylperon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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