| Electrophysiological effects of lidocaine in sick sinus syndrome. | |
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MedLine Citation:
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PMID: 7366006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrophysiological studies were performed to see the effects of lidocaine on the conduction system, particularly sinus node and atrium in 40 patients of SSS, using HBE recordings, rapid atrial pacing and atrial extrastimulus technique. Sinus cycle length, PA (P'A), AH, HV intervals, calculated SACT, and refractory periods of atrium, AV node and His-Purkinje system did not change after lidocaine. Only maximum CSRT was significantly increased with lidocaine. These results were not affected by pretreatment of atropine. In conclusion, the combining rapid atrial pacing with lidocaine may be useful to manifest the masked sinus node abnormalities. It was suggested that lidocaine directly depressed sinus node automaticity in SSS patients, without affecting perinodal tissue. Therefore, lidocaine should be used with caution in patients with known or suspected SSS. |
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Authors:
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Y Ishii; H Mitsuda; S Eno; N Fukui; T Iwamoto; K Fujitani; Y Furuta; M Yoshida; A Miyoshi; H Tateishi; M Suzukawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 21 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-06-27 Completed Date: 1980-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 27-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atropine / pharmacology Female Heart Conduction System / drug effects* Humans Lidocaine / pharmacology*, therapeutic use Male Middle Aged Refractory Period, Electrophysiological / drug effects Sick Sinus Syndrome / drug therapy* |
| Chemical | |
Reg. No./Substance:
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137-58-6/Lidocaine; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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